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Basic information

CohesinDB ID: CDBP00418791

Locus: chr21-37263577-37265365

Data sourse: ENCSR000BLD, ENCSR000BKV, GSE98367, ENCSR000BLY, GSE206145-NatGen2015, GSE62063, ENCSR153HNT

Cell type: H1-hESC, Fibroblast, SK-N-SH, K-562, Macrophage, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: NIPBL,SA1,Rad21,SMC1,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 53%, "7_Enh": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, SNAPC1, E2F5, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, ZNF507, ARID5B, E4F1, ZNF75A, SOX5, ZNF407, E2F4, DEK, ZNF528, RFX3, NR5A2, KMT2B, GATAD2A, NANOG, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, ERF, ZMYND11, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, CD74, NFRKB, DACH1, CEBPB, HNRNPL, CREB1, ZNF527, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, NR2C2, ZNF785, RELB, EP400, RUNX1, HDAC1, NKX2-2, CEBPA, IRF3, PALB2, REPIN1, TET2, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ZBTB10, ELK1, ATF2, SOX11, FOXM1, SP2, SMARCB1, GMEB1, TERF1, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, GSPT2, IKZF5, ARID2, RBM25, ZSCAN31, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, NFATC1, PAF1, SS18, ZSCAN16, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, TCF4, ZFP36, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ZNF316, FOSL1, SMARCA2, ZNF660, XBP1, HNF1A, KDM4B, ZNF101, PBX2, HNRNPK, ATF3, THRB, ZFP64, RUNX3, ZNF532, CBFB, DPF1, TP63, ZSCAN4, MITF, ZNF467, INTS11, JMJD1C, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, L3MBTL4, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, MED12, DDX20, ZNF423, ZNF350, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, ZNF239, ZNF317, ZBTB17, MTA2, ZBTB48, ZSCAN21, NONO, SRF, NBN, PBX1, KDM4A, HOMEZ, FOXP2, ZNF2, TSHZ1, RXRA, ZNF439, NKX3-1, PRDM14, MIER3, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, CIITA, EZH2phosphoT487, LDB1, AFF4, SOX13, POU4F2, ZMIZ1, ZNF18, SP3, ARNT, BACH1, DAXX, NFIB, ZNF48, PRDM9, ZEB2, NFYA, HMBOX1, PBX3, NCAPH2, ETV6, MAFB, HMGXB4, ZNF10, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, KLF7, KDM1A, BCL3, ZNF441, BRG1, ISL1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, ZNF141, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, PGR, FANCL, SOX2, PATZ1, LEO1, UBTF, RING1B, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ZNF217, ESR1, ZNF524, SND1, KLF1, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ELK4, ZNF224, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, PHF21A, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, DNMT3B, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, ZNF76, ZNF554, NFYB, NCOA2, ETV5, AHRR, BCL6, SIN3A, ERG3, NFXL1, MEF2A, MYBL2, RARA, ZNF384, CREBBP, NFYC, TAF15, ZNF35, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, NCOA1, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, HOXA9, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, ZNF318, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF223, ZNF592, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, RUVBL1, MYOD1, T, AR, KMT2D, YAP1, ZNF324, HEXIM1, DMAP1, AHR, MBD3, FOSL2, ZNF391, HMG20A, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, LYL1, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, TCF12, BAF155, NUTM1, EP300, GATA6, SOX6, CREB3, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, ATRX, EED, CHD8, BRD1, MYCN, SRC, RUNX1T1, ID3, CDK7, MLLT3, GATAD1, GMEB2, ARID3A, ASCL1, MIER1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, TRPS1, HES1, TFE3, EHF, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, ZC3H11A, MYF5, ATF1, PTBP1, ZNF45A, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, SMAD2, PBX4, NRF1, NR2C1, FOS, SUPT5H, CHD1, TGIF2, MED1, KDM6B, MYB, CEBPD, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, ZNF783, SKI, NELFA, PAX7, ZNF283, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, BHLHE22, ZNF519, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF843, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): DYRK1A,TTC3,HLCS,KCNJ15,KCNJ6,VPS26C

Function elements

Human SNPs: .

Number of somatic mutations (coding): 20

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542, ENSG00000157551,

eachgene

Deatailed information for cohesin site CDBP00418791