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Basic information

CohesinDB ID: CDBP00418832

Locus: chr21-37356357-37357538

Data sourse: GSE86191, ENCSR153HNT, ENCSR879KXD, GSE73207

Cell type: K-562, TF-1, HCT-116

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SMC3

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 66%, "14_ReprPCWk": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, PBX2, HDGF, ATF3, SMARCE1, TRIM28, CTCF, JUN, E4F1, DPF2, E2F6, E2F1, TEAD4, ZNF175, PDX1, BRD3, ID3, MTA2, ASH1L, STAT1, HINFP, NBN, NFKB2, MYC, SMARCA4, RFX1, GRHL3, FOXK2, GABPA, XRCC5, NKX3-1, IKZF1, RCOR1, LEF1, CEBPB, GRHL2, IRF1, HDAC2, GATA2, RELB, NFYB, ATF1, NKX2-2, ERG3, PBX4, ARNT, NFYA, CDK8, DIDO1, CEBPD, SCRT2, VEZF1, L3MBTL2, SETDB1, BCL11A, ZBTB7A, AFF1, FOXA2, CBX3, CREM, HOXB13, CREB3L1, KDM1A, RELA, ZNF148, SP140, HIF1A, GATA3, MGA, MAX, GATA1, MTA1, ZNF592, PKNOX1, AR, ZBTB40, EGLN2, RNF2, NCOR1, SCRT1, ILF3, JUND, CLOCK, BRD4, MAZ, ZNF24, ZNF395

Target gene symbol (double-evidenced CRMs): KCNJ6,HLCS,DYRK1A,KCNJ15,TTC3,VPS26C

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542, ENSG00000157551,

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Deatailed information for cohesin site CDBP00418832