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Basic information

CohesinDB ID: CDBP00418833

Locus: chr21-37357896-37359418

Data sourse: ENCSR230ZWH, GSE67783, GSE86191, ENCSR879KXD, GSE101921, GSE55407, GSE206145-NatGen2015, ENCSR153HNT, GSE73207, GSE111537, GSE50893, GSE94872, ENCSR917QNE

Cell type: Fibroblast, HCT-116, THP-1, TF-1, HUVEC, HCAEC, GM12890, K-562, Liver, OCI-AML-3, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 54%, "7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, XBP1, FOXA1, TFAP4, HDGF, LYL1, ATF3, RUNX3, CBFB, MECOM, TP63, JMJD1C, TEAD1, TRIM28, ELF1, ETV1, LMO2, ESR1, MLL, OCA2, JUN, TCF12, CTCF, ARID5B, LMO1, GATA6, TRIM24, RFX5, SMC1, TEAD4, KMT2B, RBPJ, EED, CHD8, BRD1, ZSCAN5D, ZNF263, MYCN, RUNX1T1, ID3, CDK7, ERF, ZBTB48, ZSCAN5A, STAT1, SRF, TBP, ERG, ETS1, MYC, SMARCA4, RAD21, FOXP2, GRHL3, GABPA, XRCC5, IKZF1, NFE2, RCOR1, ZNF750, CEBPB, EZH2, GRHL2, ZNF652, MRTFA, GABPB1, SPI1, HDAC2, GATA2, INTS13, FLI1, ZNF490, MRTFB, ETV5, RUNX1, SMC1A, CEBPA, SIN3A, ZFX, POU4F2, SMAD3, RARA, RUNX2, CDK6, PBX4, ARNT, CBFA2T3, SMARCB1, CDK8, CEBPD, MYB, ZNF680, SMAD1, ZNF3, EVI1, SETDB1, BCL11A, NR4A1, REST, ARID1A, ASH2L, TCF3, SMC3, STAG2, STAG1, MLLT1, ETV4, SKI, PPARG, FOXA2, MEIS1, NFATC1, WT1, CDK9, KDM1A, YY1, RELA, HIF1A, GATA3, TAL1, MAX, ZNF143, GATA1, HAND2, ZNF592, NCOA3, NR2F2, TCF7L2, TP53, T, AR, ZBTB16, HSF1, NOTCH3, BRD4, MAZ

Target gene symbol (double-evidenced CRMs): KCNJ6,VPS26C,HLCS,TTC3,DYRK1A,KCNJ15

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542, ENSG00000157551,

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Deatailed information for cohesin site CDBP00418833