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Basic information

CohesinDB ID: CDBP00418835

Locus: chr21-37362970-37363891

Data sourse: GSE206145, GSE67783, ENCSR153HNT

Cell type: K-562, HSPC, RPE

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 73%, "5_TxWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF426, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, SRSF7, PAX5, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, ZNF507, E4F1, ARID5B, SOX5, PAX8, DEK, E2F4, ZNF410, ZNF528, RFX3, KMT2B, ZNF555, GATAD2A, JARID2, NANOG, BRD3, ZNF263, TOP2A, POU5F1, CTBP1, ERF, ZMYND11, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, DACH1, CEBPB, HNRNPL, RBM34, CREB1, BMPR1A, GABPB1, ELF4, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, RELB, HCFC1R1, EP400, RUNX1, HDAC1, CEBPA, NKX2-2, REPIN1, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, ZXDC, TFDP1, ZBTB10, ELK1, ATF2, SOX11, FOXM1, FOXJ2, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, C11orf30, EVI1, STAT5A, GSPT2, ARID2, IKZF5, OVOL3, RBM25, AFF1, MBD2, ELL2, HMGB1, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, NFATC1, SS18, ZSCAN16, WT1, MEF2C, CREB3L1, DEAF1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, KLF4, ZFP69B, BCL11B, ZNF281, ZBTB6, MED, EGR2, ELF3, ZNF765, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ADNP, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, ZNF101, SRSF4, PBX2, ZNF596, HNRNPK, ATF3, THRB, ZC3H8, ZFP64, HNRNPUL1, RUNX3, ZNF532, CBFB, ZNF273, DPF1, ZSCAN4, TP63, MITF, BACH2, ZNF467, ZNF780A, INTS11, MAF, JMJD1C, ELF1, ZNF573, RBM39, SNAI2, KLF10, SMAD5, ZNF624, FUS, CTCF, TAF3, JUN, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, DDX20, ZNF423, ZNF677, ZNF350, PDX1, TFAP2C, RBPJ, MLX, ZNF239, MTA2, ZBTB17, ZBTB48, ZSCAN21, ZNF317, NONO, SRF, DDX5, NBN, CHD4, PBX1, ONECUT1, ZNF2, HOMEZ, KDM4A, FOXP2, TSHZ1, ZKSCAN2, LHX2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, ZKSCAN5, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, EZH2phosphoT487, LDB1, SOX13, AFF4, POU4F2, ZFP3, ZNF770, ZNF513, ZMIZ1, ZNF18, ZNF792, SP3, ARNT, BACH1, DAXX, NFIB, ZNF48, PRDM9, HMBOX1, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, MAFB, HMGXB4, ETV6, TEAD3, DIDO1, ZXDB, ZNF680, U2AF1, TAF7, KLF9, TBX5, USF1, BCL11A, SP1, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, ZNF623, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, TP53, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, SPIN1, CUX1, ZSCAN23, IRF9, ZFP42, ZNF468, PGR, FANCL, SOX2, PATZ1, LEO1, UBTF, RING1B, TFAP4, SIN3B, BMI1, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, KLF1, ZNF695, SOX9, SOX4, E2F6, TRIM24, RFX5, PRKDC, U2AF2, ZNF92, GTF2F1, GLIS1, POU2F2, CDK9-HEXIM1, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ELK4, ZMYND8, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, INO80, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, ZNF182, GATAD2B, TAF9B, ZNF76, NCOA2, NFYB, ZNF554, ETV5, BCL6, SIN3A, ZBTB12, ERG3, NFXL1, MEF2A, CREBBP, ZNF384, RARA, NFYC, TAF15, ZNF35, ZNF169, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, HOXA9, BCOR, FOXP1, AATF, NCOR2, ZNF34, CXXC4, PPARG, TBL1X, HDAC6, ZNF44, ZNF692, GTF2B, ZNF574, YY2, FOXO3, RELA, TARDBP, CHAMP1, ZNF282, SKIL, MAX, ZNF592, GFI1B, NEUROG2, NR2F1, KDM5B, TCF7L2, ZNF791, PKNOX1, ZNF547, RUVBL1, MYOD1, T, AR, PAX3-FOXO1, ZBTB16, YAP1, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, ZNF391, HMG20A, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, SFMBT1, ZFHX2, LYL1, INSM2, NFIC, ZNF362, ZBTB5, CTCFL, PRDM1, KLF14, MECOM, ZNF736, HDAC3, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, HNF1B, USF2, ZFP91, TCF12, BAF155, NUTM1, EP300, GATA6, PRDM4, GLI4, SOX6, CREB3, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, GMEB2, ARID3A, ZNF300, ZNF585B, MIER1, ZNF341, ZNF84, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, ZNF639, ZNF750, FEZF1, TRPS1, HES1, TFE3, EHF, HBP1, IRF1, ZNF664, SREBF1, ZGPAT, ZNF766, MRTFB, ATF1, PTBP1, SMC1A, CBX1, MAFG, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, SMAD2, OSR2, ZNF184, GATA4, CDK6, NRF1, GR, PBX4, SUPT5H, CHD1, FOS, MED1, RFX2, KDM6B, CEBPD, MYB, ZNF558, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, HIF2A, KLF16, NUP98-HOXA9, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, ZNF783, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF519, ZNF740, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF83, ZNF687, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF440, MEF2D, ZNF24

Target gene symbol (double-evidenced CRMs): DYRK1A,VPS26C,KCNJ6,TTC3,KCNJ15,HLCS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 11

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542, ENSG00000157551,

eachgene

Deatailed information for cohesin site CDBP00418835