- Basic information
- CohesinDB ID: CDBP00418837
- Locus: chr21-37374041-37376667
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Data sourse: ENCSR000EFJ, ENCSR956LGB, GSE86191, GSE98367, GSE138405, GSE126634, ENCSR000BLY, ENCSR879KXD, GSE206145, GSE101921, GSE62063, GSE206145-NatGen2015, ENCSR153HNT, GSE68388, GSE165895
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Cell type: RPE, Macrophage, Fibroblast, HCT-116, Hela-Kyoto, A-549, HCAEC, Ramos, IMR-90, SK-N-SH, K-562, HAP1, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.844
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 47%,
"5_TxWk": 42%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, SKI, PGR, CHD8, TBL1X, ZNF263, EBF1, FOXA2, CEBPA, ZFX, ZNF600, XBP1, ZBTB48, STAT1, FOXA1, ZNF770, ZBTB33, CDK9, HNF4G, ERG, RELA, HDGF, PRPF4, NOTCH1, ASCL1, ZNF341, NEUROD1, MYC, RUNX2, SMARCA4, HOMEZ, RUNX3, RAD21, TCF4, GRHL3, ZNF532, RXRA, OTX2, GATA3, ZNF48, SMAD4, TAL1, MAX, SUPT5H, CHD1, CEBPG, BCL11B, CEBPB, KLF5, ZEB1, ZNF558, KMT2A, MYB, TEAD3, TEAD1, EZH2, SMAD5, ESR1, TRIM28, MYOD1, CTCF, RBM22, TCF12, BCL11A, KLF1, SP1, LMO1, AR, HNF4A, MAFK, PAX8, NUTM1, GATA2, ZBTB26, BRD4, PHIP, JUND, FOXP1, FOXA3, GATAD2A, MLLT1, ZNF316
- Target gene symbol (double-evidenced CRMs): KCNJ15,KCNJ6,VPS26C,HLCS,TTC3,DYRK1A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 84
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000159267,
ENSG00000182670,
ENSG00000157538,
ENSG00000157540,
ENSG00000157542,
ENSG00000157551,
- Related loop:
chr21:36950000-36975000~~chr21:37350000-37375000,
chr21:36975000-37000000~~chr21:37350000-37375000,
chr21:37150000-37175000~~chr21:37350000-37375000,
chr21:37150000-37175000~~chr21:37375000-37400000,
chr21:37250000-37275000~~chr21:37350000-37375000,
chr21:37250000-37275000~~chr21:37375000-37400000,
chr21:37256973-37259370~~chr21:37367958-37369182,
chr21:37266529-37268622~~chr21:37364975-37369290,
chr21:37350000-37375000~~chr21:37450000-37475000,
chr21:37350000-37375000~~chr21:37625000-37650000,
chr21:37350000-37375000~~chr21:37650000-37675000,
chr21:37350000-37375000~~chr21:37900000-37925000,
chr21:37350000-37375000~~chr21:38275000-38300000,
chr21:37368049-37369282~~chr21:37563670-37565316,
chr21:37375000-37400000~~chr21:37525000-37550000,