- Basic information
- CohesinDB ID: CDBP00418840
- Locus: chr21-37380008-37381186
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Data sourse: GSE62063, GSE206145-GSE177045, ENCSR230ZWH, ENCSR917QNE
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Cell type: MCF-7, Liver, Ramos
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: NIPBL,Rad21,Mau2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 51%,
"5_TxWk": 38%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, CBX5, MEIS2, XBP1, FOXA1, PBX2, LEO1, HDGF, ATF3, ZFP64, ZNF362, CHD7, PRDM1, RUNX3, ZNF532, ATF4, ZNF189, SMARCE1, MZF1, MITF, ZNF736, JMJD1C, ELF1, TRIM28, TEAD1, ETV1, KLF6, NFE2L2, ZNF26, LMO2, ESR1, BCLAF1, OCA2, USF2, CTCF, TCF12, JUN, EP300, E4F1, ARID5B, LMO1, MNT, NUTM1, PYGO2, DPF2, ZBTB20, BAF155, E2F6, GATA6, TRIM24, ZNF407, SOX6, RAD51, DDX20, ZNF677, RFX3, TEAD4, FOXA3, ZNF92, GATAD2A, EHMT2, PDX1, TFAP2C, EED, NANOG, CHD8, POU2F2, POU5F1, MYCN, CDK7, ID3, TOP2A, CTBP1, MTA2, ZBTB17, ASH1L, ZNF317, STAT1, DUX4, ZSCAN21, ZBTB48, NBN, ARID3A, ERG2, TBP, ERG, HOXC5, ASCL1, MIER1, SMARCC2, MYC, ONECUT1, SMARCA4, EOMES, ARID1B, RAD21, GRHL3, RXRA, NKX2-1, FOXK2, GABPA, NKX3-1, IKZF1, RCOR1, LEF1, ZNF639, NFRKB, NFE2, ESRRA, CEBPB, KMT2A, CREB1, EZH2, ARHGAP35, GABPB1, ELF4, SPI1, ZNF664, ZNF257, HDAC2, GATA2, ZNF644, FLI1, SMARCA5, EP400, ZIM3, ZNF554, CC2D1A, RUNX1, MAFG, HDAC1, NKX2-2, CEBPA, LDB1, ZFX, POU4F2, SMAD3, PCBP2, ERG3, TRIM22, TWIST1, PRDM10, MYBL2, ZBTB2, ZNF384, NOTCH1, BRD9, RUNX2, CDK6, GATA4, ZNF184, ARNT, BACH1, PBX4, ZEB2, HMBOX1, FOXM1, CBFA2T3, MAFB, SUPT5H, CDK8, FOS, PBX3, MED1, ZXDB, MYB, SCRT2, PIAS1, ZMYM3, ZNF3, KLF9, NCOA1, L3MBTL2, C11orf30, EVI1, SETDB1, STAT5A, RBM22, USF1, BCL11A, MAFK, GSPT2, SP1, ARID2, REST, ZBTB7A, ZNF479, RBM25, ATF7, POU2F3, PHIP, AFF1, BCOR, FOXP1, PRDM6, SMC3, MLLT1, NFATC3, ZNF394, KLF13, PPARG, FOXA2, MTA3, CBX3, EBF1, PAF1, E2F8, ZNF600, ZNF692, GTF2B, WT1, MAFF, NFATC1, ZBTB33, CDK9, HOXB13, ZNF318, KDM1A, YY1, RELA, TARDBP, NEUROD1, JUNB, AHR, CHAMP1, TCF4, HIF1A, ZFP36, SKIL, OTX2, GATA3, MGA, TAL1, MAX, NRIP1, GATA1, MTA1, ZNF143, PLAG1, TLE3, ZNF592, SP7, NCOA3, GFI1B, NR2F1, NEUROG2, TCF7L2, PKNOX1, ZBTB6, ZSCAN22, PHOX2B, BRD2, T, KAT8, AR, PAX3-FOXO1, ZBTB40, ZNF324, EGLN2, ZNF366, EGR1, NCOR1, BRD4, ILF3, JUND, CLOCK, SCRT1, MAZ, ZNF24, ZNF316
- Target gene symbol (double-evidenced CRMs): DYRK1A,VPS26C,TTC3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 42
- Number of somatic mutations (non-coding): 0
- Related genes and loops