Deatailed information for cohesin site CDBP00418879

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  • Basic information
  • CohesinDB ID: CDBP00418879
  • Locus: chr21-37469570-37470153
  • Data sourse: GSE206145-NatGen2015, GSE67783, ENCSR153HNT
  • Cell type: K-562, Fibroblast, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 1% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.967
  • Subunit: SA1
  • CTCF binding site: non-CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 94% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 70%, "4_Tx": 13%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, ZNF426, NME2, FOXA1, RXRB, HDGF, ZBTB44, ZNF322, IKZF3, MORC2, PAX5, ZNF586, TEAD1, ZNF121, E2F5, LMO2, OCA2, E4F1, SOX5, PAX8, ZNF410, ZNF528, GATAD2A, NANOG, POU5F1, HHEX, TOP2A, ZNF263, BRD3, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, EZH1, SMARCA4, ZNF180, RFX1, FOXK2, ZNF8, ZNF398, RCOR1, NR2F6, DACH1, CEBPB, CREB1, GABPB1, ZHX2, ELF4, MIXL1, GATA2, ZNF644, FLI1, DRAP1, MXI1, RELB, EP400, RUNX1, HDAC1, CEBPA, NKX2-2, ZNF654, TBX3, SP5, TRIM22, PRDM10, ZBTB2, ZXDC, SOX11, ATF2, FOXM1, GMEB1, PML, TERF1, PIAS1, SMAD1, C11orf30, EVI1, STAT5A, IKZF5, RBM25, AFF1, NFATC3, CBFA2T2, MEF2B, CBX3, CREM, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, MPHOSPH8, JUNB, NEUROD1, TCF4, BATF, PLAG1, KLF4, ZFP69B, ZBTB6, EGR2, ELF3, ARID4B, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, HNF1A, PBX2, HNRNPK, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, ZNF532, ZNF273, DPF1, TP63, ZSCAN4, MITF, BACH2, ZNF467, CDC5L, MYOG, MAF, JMJD1C, ELF1, RBM39, SNAI2, SMAD5, CTCF, JUN, MNT, LMO1, DPF2, RYBP, IRF4, ZNF567, DDX20, PDX1, TFAP2C, ZNF317, ZBTB17, ZBTB48, MTA2, ZSCAN21, SRF, DDX5, NBN, CHD4, PBX1, ONECUT1, ZNF2, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, LEF1, MIER3, TERF2, NR3C1, ESRRA, STAT5B, KMT2A, TBL1XR1, KLF8, GRHL2, EBF3, ZKSCAN5, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, ZNF585A, LDB1, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF792, ZNF18, ARNT, DAXX, BACH1, NFIB, ZNF48, PRDM9, ZEB2, HMBOX1, NFYA, PBX3, ETV6, ZNF10, MAFB, HMGXB4, TEAD3, ZXDB, ZNF680, KLF9, USF1, SP1, TFAP2A, BCL11A, NKX2-5, ATF7, ASH2L, PRDM6, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF19, BRG1, ISL1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, TP53, ZNF334, NFKB1, ZSCAN22, PHOX2B, KAT8, TBX21, EGR1, RB1, RNF2, BRD4, JUND, CUX1, PGR, ZNF496, SOX2, PATZ1, LEO1, UBTF, TFAP4, CHD7, ZNF444, ATF4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, KLF1, SOX9, E2F6, TRIM24, RFX5, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, BAHD1, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, EZH2, ZNF652, NFE2L1, SPI1, HDAC2, GATAD2B, TAF9B, NCOA2, NFYB, ZNF554, BCL6, SIN3A, ERG3, MEF2A, RARA, ZNF384, CREBBP, ZNF35, ZNF781, HMGB2, SMAD4, ZNF518A, CBFA2T3, CDK8, ZMYM3, NCOA1, GTF3C2, RBM22, MAFK, HNF4A, NR4A1, REST, HOXA9, BCOR, FOXP1, AATF, ZNF34, PPARG, TBL1X, ZNF692, GTF2B, TCF7, ZNF318, RELA, TARDBP, CHAMP1, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, ZNF547, MYOD1, T, AR, ZNF324, AHR, FOSL2, HMG20A, ZSCAN5C, E2F7, MEIS2, SUZ12, ZFHX2, ZNF90, NFIC, ZNF362, CTCFL, PRDM1, MECOM, ZNF736, CDX2, ZNF629, THRAP3, KLF5, BCLAF1, TRIM28, ZNF26, ETV1, RCOR2, HNF1B, USF2, ZFP91, TCF12, BAF155, NUTM1, EP300, GATA6, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, MYCN, CDK7, ID3, RUNX1T1, GATAD1, ARID3A, MIER1, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, TRPS1, TFE3, ZNF664, IRF1, ZGPAT, MRTFB, ZIM3, ATF1, SMC1A, MAFG, CBX1, SIRT6, ZFX, SMAD3, PCBP2, TWIST1, NSD2, IRF2, NOTCH1, BRD9, RUNX2, ZSCAN30, GATA4, OSR2, GR, ZNF184, CDK6, PBX4, NRF1, NR2C1, SUPT5H, FOS, CHD1, MED1, CEBPD, MYB, SCRT2, VEZF1, L3MBTL2, SETDB1, KLF16, NUP98-HOXA9, ZBTB7A, POU2F3, PHIP, TCF3, ZNF283, FOXA2, RBBP5, E2F8, ZNF600, FOXF1, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF512, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): DYRK1A,TTC3,KCNJ6,VPS26C
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 33
  • Number of somatic mutations (non-coding): 3
  • Related genes and loops
  • Related gene: ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,
  • Related loop: chr21:36975000-37000000~~chr21:37475000-37500000, chr21:37150000-37175000~~chr21:37450000-37475000, chr21:37200000-37225000~~chr21:37475000-37500000, chr21:37225000-37250000~~chr21:37475000-37500000, chr21:37250000-37275000~~chr21:37450000-37475000, chr21:37350000-37375000~~chr21:37450000-37475000, chr21:37450000-37475000~~chr21:37625000-37650000, chr21:37450000-37475000~~chr21:37650000-37675000, chr21:37450000-37475000~~chr21:38150000-38175000, chr21:37475000-37500000~~chr21:37625000-37650000,
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