- Basic information
- CohesinDB ID: CDBP00418888
- Locus: chr21-37494670-37495794
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Data sourse: ENCSR000BLD, ENCSR000BKV, GSE86191, GSE138405, GSE98367, GSE111913, GSE105028, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, GSE25021
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Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, Hela-Kyoto, Monocytes, RT-112, K-562, Macrophage, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 51%,
"4_Tx": 47%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: ZNF394, GLIS1, POU2F2, SMC1A, POU5F1, ZNF660, PAF1, ZFX, GTF2B, DUX4, FOXA1, ZNF205, ZNF770, SRF, SAP130, CDK9, HOXB13, PRDM10, YY1, ZBTB2, ATF3, MYC, OSR2, RFX1, RAD21, HOMEZ, CHD7, ZNF532, RXRA, OTX2, ZEB2, GABPA, ZSCAN4, SUPT5H, ZNF736, CEBPB, SMAD1, STAG1, ZNF3, ESR1, TP53, KLF16, CTCF, RBM22, PHOX2B, BCL11A, NUTM1, MIXL1, REST, IRF4, ZNF777, DRAP1, BRD4, SMARCA5, CLOCK, FOXP1, SMC1, MRTFB, SMC3, ZZZ3, PDX1
- Target gene symbol (double-evidenced CRMs): DYRK1A,VPS26C,KCNJ6,HLCS,TTC3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 77
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159267,
ENSG00000182670,
ENSG00000157538,
ENSG00000157540,
ENSG00000157542,
- Related loop:
chr21:36975000-37000000~~chr21:37475000-37500000,
chr21:37150000-37175000~~chr21:37500000-37525000,
chr21:37166095-37167716~~chr21:37496458-37497998,
chr21:37200000-37225000~~chr21:37475000-37500000,
chr21:37225000-37250000~~chr21:37475000-37500000,
chr21:37475000-37500000~~chr21:37625000-37650000,
chr21:37496463-37497911~~chr21:37581835-37583666,
chr21:37500000-37525000~~chr21:37625000-37650000,