- Basic information
- CohesinDB ID: CDBP00418900
- Locus: chr21-37519283-37520043
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Data sourse: GSE67783, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE116344
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Cell type: RPE, Fibroblast, RH4, RT-112, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
95% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 65%,
"15_Quies": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, PGR, SOX2, XBP1, FOXA1, LEO1, ZFHX2, ATF3, NFIC, ZFP64, ZNF362, THAP1, RUNX3, CHD7, ZNF532, ATF4, PAX5, SFPQ, JMJD1C, TEAD1, BCLAF1, TRIM28, KLF6, RBM39, ZNF121, LMO2, ESR1, CTCF, TCF12, EP300, NUTM1, ZBTB20, GATA6, PAX8, TEAD4, GLIS1, POU2F2, CHD8, NANOG, MYCN, POU5F1, TOP2A, ID3, ZNF263, ZBTB17, ZBTB48, ZSCAN5A, STAT1, DUX4, MLLT3, DDX5, ERG2, ERG, OGG1, ZNF341, MYC, SMARCA4, EOMES, RAD21, GRHL3, APC, XRCC5, IKZF1, CEBPB, CREB1, EZH2, EBF3, SPI1, EHF, GATA2, FLI1, NFIL3, ZIM3, RUNX1, SMC1A, CEBPA, SIRT6, NKX2-2, ZFX, ZNF770, TET2, ERG3, CDK6, GATA4, GR, ARNT, BACH1, SOX11, ZNF48, PRDM9, HMBOX1, HMGB2, ETV6, SUPT5H, CDK8, MED1, CSNK2A1, PML, SCRT2, RBM22, ARID2, POU2F3, BCOR, PRDM6, SMC3, MLLT1, STAG1, TRP47, PPARG, FOXA2, MTA3, PAF1, E2F8, NFATC1, GTF2B, WT1, ZBTB33, MEF2C, HOXB13, MPHOSPH8, KDM1A, YY1, RELA, ZNF510, ISL1, SP140, ZIC2, HIF1A, OTX2, TAL1, ZNF143, AGO2, KLF4, CEBPG, ZNF141, NR2F2, NEUROG2, KDM5B, EGR2, PHOX2B, AR, MYNN, BRD4, SCRT1, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): KCNJ6,DYRK1A,TTC3
- Function elements
- Human SNPs: Mean_spheric_corpuscular_volume
- Number of somatic mutations (coding): 4
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000182670,
ENSG00000157540,
ENSG00000157542,
- Related loop:
chr21:37050000-37075000~~chr21:37525000-37550000,
chr21:37150000-37175000~~chr21:37500000-37525000,
chr21:37200000-37225000~~chr21:37525000-37550000,
chr21:37225000-37250000~~chr21:37525000-37550000,
chr21:37375000-37400000~~chr21:37525000-37550000,
chr21:37500000-37525000~~chr21:37625000-37650000,
chr21:37525000-37550000~~chr21:37625000-37650000,
chr21:37525000-37550000~~chr21:38075000-38100000,
chr21:37525000-37550000~~chr21:38150000-38175000,