- Basic information
- CohesinDB ID: CDBP00418905
- Locus: chr21-37530593-37532671
-
Data sourse: GSE67783, ENCSR000BKV, GSE86191, ENCSR000BSB, GSE138405, GSE116868, GSE25021, GSE111913, GSE105028, GSE206145-NatGen2015, GSE206145, ENCSR153HNT, GSE68388, GSE83726, GSE131606, GSE50893
-
Cell type: MCF-7, GM12892, GM2630, Fibroblast, HCT-116, Hela-Kyoto, MB157, RH4, RPE, GM12891, GM19238, H9-hESC, RT-112, K-562, HSPC, HuCC-T1, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.811
- Subunit: SA1,Rad21,SA2,SMC1
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
95% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"14_ReprPCWk": 23%,
"7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: TRIM25, PGR, MEIS2, FOXA1, SUZ12, PBX2, ATF3, NFIC, HNRNPUL1, RUNX3, KLF14, CBFB, TP63, KLF5, TRIM28, RBM39, KLF6, ESR1, CTCF, TCF12, EP300, KLF1, BAF155, PAX8, DEK, E2F1, RBPJ, TFAP2C, POU2F2, MYCN, RUNX1T1, ZBTB48, ZSCAN5A, STAT1, ERG2, ERG, ASCL1, OGG1, ETS1, MYC, RAD21, NKX2-1, STAT3, XRCC5, PRDM14, NR3C1, HNRNPL, EZH2, BMPR1A, SPI1, MXD3, RUNX1, SMC1A, SIRT6, ZFX, ZNF534, TET2, ZNF770, ERG3, RARA, RUNX2, OSR2, GR, ZNF184, SMARCB1, CHD1, SNRNP70, MED1, MYB, ZNF3, KLF9, C11orf30, TBX5, RBM22, MAFK, BCL11A, SP1, ARID2, ZBTB7A, HNRNPLL, PHIP, SMC3, STAG1, TRP47, AGO1, EBF1, PAF1, WT1, MAFF, ZNF580, YY1, RELA, NEUROD1, SP140, ZIC2, OTX2, MAX, GATA1, AGO2, PLAG1, KLF4, NR2F1, EGR2, BRD2, AR, HSF1, RNF2, BRD4, CLOCK, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): DYRK1A,KCNJ6,TTC3,VPS26C
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000182670,
ENSG00000157538,
ENSG00000157540,
ENSG00000157542,
- Related loop:
chr21:37050000-37075000~~chr21:37525000-37550000,
chr21:37200000-37225000~~chr21:37525000-37550000,
chr21:37225000-37250000~~chr21:37525000-37550000,
chr21:37375000-37400000~~chr21:37525000-37550000,
chr21:37525000-37550000~~chr21:37625000-37650000,
chr21:37525000-37550000~~chr21:38075000-38100000,
chr21:37525000-37550000~~chr21:38150000-38175000,
chr21:37527492-37529167~~chr21:37581619-37583658,
chr21:37532652-37534151~~chr21:37556775-37558385,