Deatailed information for cohesin site CDBP00418906

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  • Basic information
  • CohesinDB ID: CDBP00418906
  • Locus: chr21-37532943-37533875
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BSB, GSE116868, ENCSR150EFU, GSE105028, GSE121355, GSE131606, GSE108869, GSE25021, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE51234, GSE112028, GSE130135, ENCSR703TNG, GSE106870, ENCSR193NSH, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, ENCSR000BTQ, GSE38395, ENCSR853VWZ, GSE131956, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, ENCSR335RKQ, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS, GSE38411
  • Cell type: GM10847, GM2610, CVB-hiPSC, GM19240, CVI-hiPSC, GP5d, HuCC-T1, H9-hESC, RPE, GM2630, Ishikawa, GM12890, HeLa-S3, hLCL, IMR-90, BCBL-1, K-562, DKO, H1-hESC, MB157, Lymphoblast, GM12878, GM2588, GBM39, RT-112, HeLa-Tet-On, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, GM19238, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 17% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.622
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: non-Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 95% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "14_ReprPCWk": 27%, "15_Quies": 21%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOSL1, TRIM25, HMGN3, MEIS2, XBP1, TBL1X, PATZ1, FOXA1, RBFOX2, PBX2, MLL4, ZFHX2, TFAP4, HDGF, ATF3, NFIC, ZFP64, RUNX3, WDHD1, PRDM1, KLF14, SMARCE1, PAX5, TP63, MITF, ZNF320, CDX2, ZNF629, MAF, KLF5, ELF1, BCLAF1, TRIM28, KLF6, SNAI2, NFE2L2, TEAD1, ESR1, HDAC8, USF2, JUN, TCF12, SND1, EP300, KLF1, BAF155, MNT, ZBTB20, CTCF, DPF2, SOX4, PAX8, E2F6, IRF4, DEK, ZNF423, E2F1, ZNF528, TEAD4, GTF2F1, RBPJ, TFAP2C, EED, GLIS1, POU2F2, ZSCAN5D, ZNF263, MYCN, POU5F1, ID3, BRD3, CTBP1, ZSCAN21, MTA2, ZBTB48, ZSCAN5A, SRF, SAP130, NBN, ERG2, TBP, HOXC5, ERG, ZNF341, NFKB2, MYC, SMARCA4, TSHZ1, ARID1B, RAD21, KDM4A, GRHL3, NKX2-1, STAT3, XRCC5, ZNF398, IKZF1, RCOR1, TERF2, ZNF639, HNRNPH1, NR3C1, CEBPB, ESRRA, CREB1, EPAS1, EZH2, GRHL2, ZHX2, SPI1, IRF1, KLF17, HDAC2, INTS13, GATA2, GATAD2B, FLI1, MXI1, RELB, MRTFB, NCOA2, ATF1, RUNX1, BCL6, ZBTB24, CBX1, NKX2-2, HDAC1, SMC1A, ZNF335, ZFX, SIN3A, AFF4, SMAD3, TET2, ERG3, SMARCC1, PRDM10, ZNF18, CREBBP, ZNF35, ZBTB2, RUNX2, OSR2, ZNF184, NRF1, PBX4, ARNT, ZBTB10, BACH1, ZEB2, PBX3, FOS, CDK8, SMARCB1, CHD1, MED1, ZEB1, ZNF3, NR1H2, KLF9, L3MBTL2, TBX5, HIF2A, KLF16, NIPBL, SP1, BCL11A, TFAP2A, ZBTB7A, ZNF479, ATF7, ZHX1, HNRNPLL, PHIP, TCF3, GLIS2, SMC3, MLLT1, STAG1, NFATC3, TRP47, CBFA2T2, MEF2B, CBX3, MTA3, CREM, CHD2, EBF1, PAF1, ZNF600, ZSCAN16, ZBED1, ZNF692, WT1, ZNF823, BCL3, YY1, RELA, JUNB, NEUROD1, MCM3, SP140, ZIC2, HIF1A, GATA3, BATF, MAX, ZNF143, MTA1, GATA1, AGO2, PLAG1, CBX2, KLF4, SP7, TCF7L2, NR2F1, KDM5B, TP53, PKNOX1, ZNF334, NFKB1, EGR2, BRD2, TBX21, BHLHE40, AR, ZNF324, EGLN2, ZBTB42, EGR1, RB1, HEXIM1, HSF1, RNF2, NCOR1, JUND, BRD4, ILF3, CLOCK, MAZ, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): VPS26C,KCNJ6,TTC3,DYRK1A
  • Function elements
  • Human SNPs: Systolic_blood_pressure
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 2
  • Related genes and loops
  • Related gene: ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,
  • Related loop: chr21:37050000-37075000~~chr21:37525000-37550000, chr21:37200000-37225000~~chr21:37525000-37550000, chr21:37225000-37250000~~chr21:37525000-37550000, chr21:37375000-37400000~~chr21:37525000-37550000, chr21:37525000-37550000~~chr21:37625000-37650000, chr21:37525000-37550000~~chr21:38075000-38100000, chr21:37525000-37550000~~chr21:38150000-38175000, chr21:37527492-37529167~~chr21:37581619-37583658, chr21:37532652-37534151~~chr21:37556775-37558385,
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