Deatailed information for cohesin site CDBP00418912

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  • Basic information
  • CohesinDB ID: CDBP00418912
  • Locus: chr21-37545632-37548152
  • Data sourse: ENCSR000BLD, GSE72082, GSE126634, GSE105028, GSE108869, ENCSR000BTU, GSE93080, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE130135, GSE106870, GSE145327, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE97394, ENCSR167MTG, GSE110061, ENCSR000EDE, ENCSR153HNT, GSE126990, GSE50893, ENCSR000ECS, GSE73207
  • Cell type: CVB-hiPSC, CVI-hiPSC, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, K-562, H1-hESC, TF-1, GM12878, HUES9, HAP1, HUES64, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, HCAEC, GM19238, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 11% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.756
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: non-Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 95% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 32%, "7_Enh": 21%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, ZNF391, PGR, SMARCA2, ZNF660, ZSCAN5C, MEIS2, XBP1, PATZ1, ZNF101, FOXA1, PBX2, ZNF596, ZFHX2, LYL1, INSM2, NFIC, CDK7, ZFP64, RUNX1T1, CTCFL, ZBTB44, PRDM1, IKZF3, RUNX3, CBFB, EGR1, ZNF189, SMARCE1, MECOM, TP63, ZSCAN4, MZF1, ZNF467, ZNF629, JMJD1C, ELF1, ZNF121, TRIM28, TEAD1, SNAI2, NFE2L2, KLF10, ZNF624, ESR1, OCA2, LMO2, ZNF561, ZFP91, CTCF, TCF12, ZNF577, EP300, KLF1, ZNF695, ZBTB20, LMO1, ARID5B, DPF2, PRDM4, TRIM24, SOX6, ZNF423, E2F1, ZNF528, SMC1, TEAD4, KLF3, PDX1, EED, GLIS1, ZSCAN5D, MYCN, POU5F1, BRD3, ZNF263, ID3, ZNF778, ZSCAN21, ZBTB17, ZBTB48, ZSCAN5A, ZBTB1, CTBP1, MTA2, SRF, ZNF488, ZMYND8, NBN, STAT1, SP4, ERG, ZBTB21, ZNF341, ZBTB8A, ETS1, MYC, SMARCA4, ZNF2, TSHZ1, RAD21, FOXP2, GRHL3, ZKSCAN2, ARID1B, GABPA, STAT3, UBN1, NKX3-1, IKZF1, NFE2, RCOR1, ZNF639, ZNF285, NR3C1, CEBPB, KMT2A, EZH2, KLF8, FEZF1, MRTFA, ZHX2, SPI1, ZNF664, KLF17, HDAC2, GATA2, ZNF146, ZSCAN29, SIX2, FLI1, MXI1, MRTFB, ZNF76, ZNF554, ATF1, RUNX1, SMC1A, MAFG, HDAC1, NKX2-2, ZNF707, CEBPA, ZNF335, ZFX, NFKBIA, AFF4, LDB1, SMAD3, ZBTB12, ZNF770, ERG3, ZNF513, TWIST1, PRDM10, SMARCC1, ZNF18, CBX4, ZNF35, RUNX2, ZSCAN30, OSR2, ZNF184, SP3, ARNT, NRF1, PBX4, HMGB2, ATF2, ZEB2, ZNF518A, ETV6, FOXM1, ZNF10, SP2, CDK8, FOS, SMARCB1, CBFA2T3, PML, ZXDB, ZNF558, SCRT2, MYB, SMAD1, CEBPD, ZNF3, ZMYM3, KLF9, C11orf30, L3MBTL2, TBX5, SETDB1, EVI1, KLF16, ZNF317, BCL11A, USF1, OVOL3, ZBTB7A, ZHX1, ATF7, PHIP, TCF3, BCOR, PRDM6, ZNF623, SMC3, ELL2, ZNF34, STAG1, STAG2, CXXC4, ZNF394, PAX7, MLLT1, TRP47, CBFA2T2, PPARG, TBL1X, FOXA2, ZNF716, MEIS1, RBBP5, CBX3, ZNF600, ZNF692, ZSCAN16, WT1, ZNF30, ZNF574, ZBTB33, CDK9, ZNF580, KLF7, HOXB13, KDM1A, YY1, RELA, NEUROD1, ZNF610, SP140, ZIC2, HIF1A, ZFP36, OTX2, GATA3, NCOR1, TAL1, MAX, ZNF449, ZNF143, GATA1, BCL6, ZFP69B, BCL11B, SP7, NCOA3, GFI1B, TCF7L2, ZNF213, PKNOX1, ZSCAN22, MYOD1, BRD2, ZNF843, AR, ZBTB16, ZBTB40, ZNF324, ZNF366, HEXIM1, ZBTB42, RB1, HSF1, ZBTB26, NOTCH3, BRD4, SCRT1, MYNN, JUND, RNF2, MAZ, ILF3, ZSCAN23, ZNF24, AHR
  • Target gene symbol (double-evidenced CRMs): VPS26C,DYRK1A,KCNJ6,TTC3
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 16
  • Related genes and loops
  • Related gene: ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,
  • Related loop: chr21:36950000-36975000~~chr21:37550000-37575000, chr21:36975000-37000000~~chr21:37550000-37575000, chr21:37050000-37075000~~chr21:37525000-37550000, chr21:37200000-37225000~~chr21:37525000-37550000, chr21:37200000-37225000~~chr21:37550000-37575000, chr21:37225000-37250000~~chr21:37525000-37550000, chr21:37225000-37250000~~chr21:37550000-37575000, chr21:37250000-37275000~~chr21:37550000-37575000, chr21:37375000-37400000~~chr21:37525000-37550000, chr21:37525000-37550000~~chr21:37625000-37650000, chr21:37525000-37550000~~chr21:38075000-38100000, chr21:37525000-37550000~~chr21:38150000-38175000, chr21:37546322-37547628~~chr21:37581687-37583761, chr21:37550000-37575000~~chr21:37650000-37675000, chr21:37550000-37575000~~chr21:38350000-38375000,
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