Deatailed information for cohesin site CDBP00418915

Check detailed explainations here

  • Basic information
  • CohesinDB ID: CDBP00418915
  • Locus: chr21-37550790-37553366
  • Data sourse: ENCSR000BLD, ENCSR167MTG, ENCSR338DUC, GSE206145-GSE177045, GSE67783, ENCSR000BKV, GSE72082, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE112028, GSE130135, GSE25021
  • Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, HEK293T, Hep-G2, K-562, HeLa-Tet-On, HSPC, HuCC-T1
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 5% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.878
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: non-Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 95% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 29%, "7_Enh": 28%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, RXRB, KDM3A, HDGF, ZBTB44, ZNF322, PAX5, TEAD1, ZNF121, OCA2, ZNF561, SOX5, PAX8, E2F4, GATAD2A, JARID2, POU5F1, BRD3, ZNF263, CTBP1, DUX4, STAT1, SAP130, ERG, ZNF597, ZBTB8A, NFKB2, SMARCA4, RFX1, FOXK2, RCOR1, NR2F6, DACH1, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, NR2C2, RELB, RUNX1, HDAC1, CEBPA, NKX2-2, TET2, SP5, TRIM22, SMARCC1, PRDM10, ATF2, FOXM1, SMARCB1, TERF1, C11orf30, IKZF5, NFATC3, CBFA2T2, MEF2B, CBX3, CREM, SS18, WT1, NEUROD1, JUNB, MCM3, ZFP36, BATF, PLAG1, MED, EGR2, ELF3, ARID4B, RXR, ZBTB26, HSF1, NCOR1, ILF3, ZNF316, FOSL1, XBP1, PBX2, ATF3, ZFP64, RUNX3, ZNF532, CBFB, MITF, MYOG, ELF1, RBM39, CTCF, JUN, MNT, DPF2, IRF4, ZNF423, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, ZSCAN21, ZNF317, SRF, DDX5, NBN, PBX1, HOMEZ, PRDM14, MIER3, TERF2, NR3C1, ESRRA, KMT2A, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, LDB1, SOX13, AFF4, ZNF770, ZNF18, ARNT, DAXX, ZNF48, PRDM9, ZEB2, PBX3, NCAPH2, ETV6, HMGXB4, TEAD3, DIDO1, ZNF680, U2AF1, TBX5, USF1, BCL11A, TFAP2A, SP1, NKX2-5, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, ZNF394, TRP47, MTA3, EBF1, MAFF, ZNF580, BCL3, KDM1A, ZIC2, TAL1, ZNF143, MTA1, NFKB1, BRD2, KAT8, TBX21, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, PGR, CBX5, PATZ1, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ESR1, TP73, SND1, SOX4, E2F6, TRIM24, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, HNF4G, OGG1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, SPI1, HDAC2, GATAD2B, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, CREBBP, ZNF384, ZNF133, SMAD4, CBFA2T3, SNRNP70, NCOA1, ZNF22, MAFK, HNF4A, REST, HNRNPLL, BCOR, FOXP1, AATF, PPARG, TBL1X, GTF2B, RELA, TARDBP, SKIL, MGA, MAX, GFI1B, BAP1, NR2F1, NEUROG2, TCF7L2, KDM5B, PKNOX1, MYOD1, PAX3-FOXO1, AR, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, MEIS2, ZFHX2, NFIC, ZNF362, PRDM1, MECOM, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, EP300, GATA6, PRDM4, SOX6, E2F1, TEAD4, FOXA3, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ZNF300, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, FEZF1, HES1, TFE3, ZGPAT, ATF1, SMC1A, MAFG, SIRT6, ZFX, SMAD3, PCBP2, RUNX2, GATA4, OSR2, ZNF184, NR2C1, FOS, MED1, CEBPD, ZNF3, L3MBTL2, SETDB1, KLF16, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, PAX7, FOXA2, ZNF600, MIER2, ZBTB33, CDK9, YY1, SP140, HIF1A, OTX2, ZNF449, GATA1, CEBPG, SP7, NR2F2, NFKBIZ, BHLHE40, ZBTB40, MYNN, MAZ, MEF2D, ZNF24
  • Target gene symbol (double-evidenced CRMs): VPS26C,TTC3,KCNJ6,HLCS
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 19
  • Related genes and loops
  • Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157542,
  • Related loop: chr21:36950000-36975000~~chr21:37550000-37575000, chr21:36975000-37000000~~chr21:37550000-37575000, chr21:37050000-37075000~~chr21:37525000-37550000, chr21:37200000-37225000~~chr21:37525000-37550000, chr21:37200000-37225000~~chr21:37550000-37575000, chr21:37225000-37250000~~chr21:37525000-37550000, chr21:37225000-37250000~~chr21:37550000-37575000, chr21:37250000-37275000~~chr21:37550000-37575000, chr21:37375000-37400000~~chr21:37525000-37550000, chr21:37525000-37550000~~chr21:37625000-37650000, chr21:37525000-37550000~~chr21:38075000-38100000, chr21:37525000-37550000~~chr21:38150000-38175000, chr21:37532652-37534151~~chr21:37556775-37558385, chr21:37546322-37547628~~chr21:37581687-37583761, chr21:37550000-37575000~~chr21:37650000-37675000, chr21:37550000-37575000~~chr21:38350000-38375000,
eachgene