Deatailed information for cohesin site CDBP00418921

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  • Basic information
  • CohesinDB ID: CDBP00418921
  • Locus: chr21-37562174-37566445
  • Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE64758, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE76893, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
  • Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, Transformed-RPE1, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, GM19238, Neutrophil, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 64% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.300
  • Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: non-Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 95% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "2_TssAFlnk": 26%, "7_Enh": 21%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, TRIM25, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, ZBTB44, IKZF3, MORC2, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, E2F5, LMO2, OCA2, PITX3, HDAC8, ZNF561, ZNF577, ZNF507, E4F1, ARID5B, SOX5, PYGO2, PAX8, ZNF407, E2F4, DEK, ZNF410, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, BRD3, ZNF263, TOP2A, POU5F1, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, ZNF197, ZNF398, RCOR1, NUFIP1, DACH1, NFRKB, NR2F6, CEBPB, CREB1, BMPR1A, GABPB1, ELF4, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, DRAP1, NR2C2, RELB, EP400, RUNX1, HDAC1, CEBPA, IRF3, NKX2-2, ZNF707, REPIN1, TET2, ZNF654, TBX3, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, ZNF584, GMEB1, PML, PIAS1, SMAD1, C11orf30, EVI1, STAT5A, GSPT2, ARID2, IKZF5, RBM25, ZSCAN31, AFF1, MBD2, ELL2, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, ZFP36, TCF4, BATF, PLAG1, KLF4, ZFP69B, BCL11B, ZNF281, ZKSCAN8, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, ZNF101, PBX2, ATF3, ZFP64, RUNX3, CBFB, ZNF273, DPF1, TP63, ZSCAN4, MITF, BACH2, ZNF467, JMJD1C, MAF, INTS11, ELF1, MYOG, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF423, DDX20, ZNF280A, PDX1, RBPJ, TFAP2C, ZNF239, MTA2, ZBTB17, ZBTB48, ZSCAN21, ZNF317, NONO, SRF, DDX5, NBN, PHB2, PBX1, ONECUT1, KDM4A, ZNF2, TSHZ1, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, LEF1, TERF2, MIER3, TEAD2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, ZBTB24, LDB1, AFF4, SOX13, ZNF770, ZMIZ1, SP3, ARNT, BACH1, NFIB, DAXX, ZNF48, PRDM9, ZEB2, NFYA, HMBOX1, PBX3, NCAPH2, ZNF10, MAFB, ETV6, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, ZNF623, SMC3, STAG1, STAG2, MLLT1, ZNF394, TRP47, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, MTA1, TP53, ZNF334, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, ZSCAN23, IRF9, PGR, SOX2, PATZ1, LEO1, RING1B, UBTF, TFAP4, SIN3B, BMI1, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, KLF1, SOX4, ZNF714, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZSCAN5A, ZMYND8, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, ZNF24, PHF21A, KLF12, NKX2-1, GABPA, STAT3, IKZF1, SRSF3, EZH2, MRTFA, NFE2L1, PHF8, SPI1, HDAC2, INTS13, ZNF880, GATAD2B, ZNF777, ZNF76, NFYB, ZNF554, NCOA2, ETV5, GTF2A2, BCL6, SIN3A, ZFP37, ERG3, MYBL2, RARA, ZNF35, CREBBP, NFYC, ZNF354B, TAF15, ZNF384, HMGB2, ZNF518A, SMAD4, CBFA2T3, CDK8, CSNK2A1, ZEB1, SUPT16H, NCOA1, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ILK, CXXC4, PTTG1, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, YY2, ZNF318, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, ZNF791, NEUROG2, PKNOX1, MYOD1, T, AR, KMT2D, ZNF324, HEXIM1, ZNF395, AHR, FOSL2, DMAP1, ZNF391, HMG20A, ZSCAN5C, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, LYL1, INSM2, NFIC, ZNF362, ZBTB5, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, ZNF506, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, HNF1B, USF2, ZFP91, TCF12, BAF155, EP300, GATA6, GLI4, CREB3, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, SRC, CDK7, ID3, RUNX1T1, HINFP, GATAD1, ARID3A, ASCL1, MIER1, ZNF341, EOMES, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, TRPS1, TFE3, IRF1, SREBF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, SMC1A, CBX1, MAFG, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, TWIST1, NSD2, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, GATA4, CDK6, ZNF184, OSR2, GR, NRF1, PBX4, NR2C1, SUPT5H, CHD1, FOS, MED1, KDM6B, MYB, ZNF558, SCRT2, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, ZNF589, YY1, ZNF148, ASXL1, ZNF610, SP140, HIF1A, OTX2, ZNF740, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF83, ZNF687, ZNF213, ZNF843, BHLHE40, NFKBIZ, PTRF, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, MEF2D, BRCA1
  • Target gene symbol (double-evidenced CRMs): VPS26C,TTC3,KCNJ6,DYRK1A,HLCS
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 16
  • Related genes and loops
  • Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,
  • Related loop: chr21:36950000-36975000~~chr21:37550000-37575000, chr21:36975000-37000000~~chr21:37550000-37575000, chr21:37166297-37167797~~chr21:37563454-37566884, chr21:37200000-37225000~~chr21:37550000-37575000, chr21:37219712-37222158~~chr21:37563130-37566817, chr21:37220147-37222181~~chr21:37562857-37565652, chr21:37220161-37222184~~chr21:37563560-37566497, chr21:37225000-37250000~~chr21:37550000-37575000, chr21:37250000-37275000~~chr21:37550000-37575000, chr21:37368049-37369282~~chr21:37563670-37565316, chr21:37532652-37534151~~chr21:37556775-37558385, chr21:37550000-37575000~~chr21:37650000-37675000, chr21:37550000-37575000~~chr21:38350000-38375000, chr21:37562596-37565431~~chr21:37641584-37643972, chr21:37562693-37565509~~chr21:37657926-37660241,
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