- Basic information
- CohesinDB ID: CDBP00418927
- Locus: chr21-37580656-37583729
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, Liver, GP5d, Transformed-RPE1, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, THP-1, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 70% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.278
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
95% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 56%,
"7_Enh": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, FOXO1, POU2F2, PPARG, POU5F1, RUNX1T1, NFATC1, XBP1, GTF2B, SAP130, RXRB, TFAP4, RELA, RARA, PBX1, ETS1, MYC, HOMEZ, RUNX3, PRDM1, GRHL3, RAD21, ZNF429, ARNT, SMAD4, TAL1, MAX, STAT3, IKZF1, NR2F6, MED1, MYOG, TEAD3, TRIM28, KMT2A, ZNF3, LMO2, EVI1, MYOD1, USF2, ELF3, CTCF, TCF12, BCL11A, SPI1, TFE3, USF1, MIXL1, SOX5, IKZF5, GATA2, ZNF644, IRF4, BRD4, TCF3, ZNF175, MYF5
- Target gene symbol (double-evidenced CRMs): DYRK1A,TTC3,HLCS,VPS26C
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 12
- Related genes and loops
- Related gene:
ENSG00000159267,
ENSG00000182670,
ENSG00000157538,
ENSG00000157540,
- Related loop:
chr21:36938603-36940392~~chr21:37581749-37583648,
chr21:36976410-36978425~~chr21:37581857-37583566,
chr21:36976414-36978410~~chr21:37581771-37583697,
chr21:36976414-36978490~~chr21:37581977-37583577,
chr21:37078878-37080096~~chr21:37582024-37583384,
chr21:37150000-37175000~~chr21:37575000-37600000,
chr21:37165914-37167790~~chr21:37581870-37583744,
chr21:37165924-37167794~~chr21:37581806-37583572,
chr21:37165928-37167803~~chr21:37581799-37583709,
chr21:37165939-37167680~~chr21:37581819-37583687,
chr21:37165948-37167801~~chr21:37581734-37583636,
chr21:37165963-37167815~~chr21:37581749-37583648,
chr21:37166201-37167778~~chr21:37581833-37583520,
chr21:37219743-37222181~~chr21:37581749-37583648,
chr21:37219750-37222176~~chr21:37580199-37581548,
chr21:37219773-37222194~~chr21:37581619-37583704,
chr21:37219804-37222187~~chr21:37581794-37583687,
chr21:37225000-37250000~~chr21:37575000-37600000,
chr21:37250000-37275000~~chr21:37575000-37600000,
chr21:37461848-37464293~~chr21:37581652-37583693,
chr21:37496463-37497911~~chr21:37581835-37583666,
chr21:37527492-37529167~~chr21:37581619-37583658,
chr21:37546322-37547628~~chr21:37581687-37583761,