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Basic information

CohesinDB ID: CDBP00418946

Locus: chr21-37625250-37626011

Data sourse: GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 95% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 38%, "5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SOX2, XBP1, FOXA1, PBX2, TSC22D4, ATF3, NFIC, CHD7, ZNF532, PAX5, CDX2, TEAD1, TRIM28, ZNF217, ESR1, CTCF, TCF12, JUN, EP300, NUTM1, GATA6, DPF2, E2F6, IRF4, SMC1, TFAP2C, RBPJ, POU2F2, CHD8, MYCN, TOP2A, CTBP1, MTA2, ZBTB48, ERG, NFKB2, ETS1, MYC, GRHL3, BATF3, XRCC5, IKZF1, CEBPB, ESRRA, STAT5B, TRPS1, SPI1, HDAC2, FLI1, SMARCA5, RELB, RUNX1, SIN3A, ZFX, POU4F2, CBX8, TRIM22, PRDM10, CREBBP, ZNF384, ARNT, TFDP1, ATF2, PRDM9, FOXM1, MAFB, NR2C1, FOS, ETV6, PBX3, MED1, ZEB1, SP1, BCL11A, ATF7, CTBP2, SMC3, STAG1, MEF2B, PPARG, TBL1X, EBF1, WT1, HOXB13, BCL3, YY1, RELA, JUNB, SP140, ZFP36, HIF1A, SKIL, GATA3, BATF, TAL1, MAX, ZNF143, NCOA3, NR2F2, NR2F1, ZNF687, PKNOX1, ZNF334, NFKB1, TBX21, BHLHE40, AR, PAX3-FOXO1, HSF1, NOTCH3, BRD4, IKZF2, MAZ, AHR

Target gene symbol (double-evidenced CRMs): VPS26C,KCNJ6,TTC3,DYRK1A,HLCS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 118

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

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Deatailed information for cohesin site CDBP00418946