- Basic information
- CohesinDB ID: CDBP00418948
- Locus: chr21-37631492-37632217
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Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE105028, GSE131606, ENCSR917QNE, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE67783, GSE101921, GSE206145-NatGen2015, GSE106870, GSE85526, ENCSR000ECE, ENCSR000BMY, GSE97394, GSE38395, GSE111913, GSE68388, GSE50893, GSE64758
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Cell type: GM2610, CVB-hiPSC, Liver, HuCC-T1, H9-hESC, GM2630, Fibroblast, HEKn, GM12890, hLCL, GM2255, DKO, H1-hESC, GM12878, GM2588, RT-112, HUES64, GM12892, MCF-10A, HCAEC, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 8% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.767
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
95% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 27%,
"14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: SOX2, MEIS2, XBP1, FOXA1, PBX2, MLL4, ATF3, NFIC, CHD7, RUNX3, ZNF532, CBFB, PAX5, TP63, ZNF320, TEAD1, TRIM28, BCLAF1, ELF1, SNAI2, ESR1, TP73, CTCF, JUN, TCF12, EP300, NUTM1, PAX8, DPF2, SOX4, E2F6, IRF4, SMC1, TEAD4, ZNF92, PDX1, RBPJ, EED, JARID2, POU2F2, CHD8, BRD1, ZSCAN5D, BRD3, NANOG, TOP2A, ID3, MTA2, STAT1, NBN, HNF4G, ZNF597, NFKB2, ETS1, EZH1, MYC, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, XRCC5, IKZF1, RCOR1, NR3C1, ESRRA, SRSF3, CEBPB, CREB1, CCAR2, EZH2, GRHL2, SPI1, EHF, HDAC2, GATA2, GATAD2B, RELB, NCOA2, CBX1, SMC1A, HDAC1, EZH2phosphoT487, NKX2-2, CEBPA, SIN3A, ZFX, SMAD3, ERG3, TRIM22, CREBBP, ZBTB2, ZNF133, CDK6, ARNT, PBX4, BACH1, ATF2, SMAD4, ETV6, FOXM1, FOS, CDK8, MED1, ZEB1, PIAS1, NCOA1, L3MBTL2, SETDB1, SP1, BCL11A, NIPBL, HNF4A, REST, ZBTB7A, ATF7, ASH2L, CTBP2, TCF3, BCOR, FOXP1, SMC3, MLLT1, STAG2, STAG1, NFATC3, MEF2B, FOXA2, MTA3, CREM, ZNF207, RBBP5, E2F8, EBF1, GTF2B, WT1, TCF7, CDK9, KDM1A, YY1, RELA, TARDBP, JUNB, ZFP36, HIF1A, SKIL, PCGF1, GATA3, BATF, MGA, TAL1, MAX, NRIP1, ZNF143, GATA1, SPIB, GFI1B, NR2F2, NR2F1, KDM5B, TP53, ZNF334, NFKB1, MYOD1, PHOX2B, ELF3, TBX21, NFKBIZ, AR, BHLHE40, TAF1, EGR1, HSF1, RNF2, IKZF2, JUND, BRD4, NOTCH3, TBX2, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): KCNJ6,HLCS,VPS26C,DYRK1A,TTC3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 18
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159267,
ENSG00000182670,
ENSG00000157538,
ENSG00000157540,
ENSG00000157542,
- Related loop:
chr21:36975000-37000000~~chr21:37625000-37650000,
chr21:37150000-37175000~~chr21:37625000-37650000,
chr21:37175000-37200000~~chr21:37625000-37650000,
chr21:37200000-37225000~~chr21:37625000-37650000,
chr21:37225000-37250000~~chr21:37625000-37650000,
chr21:37250000-37275000~~chr21:37625000-37650000,
chr21:37350000-37375000~~chr21:37625000-37650000,
chr21:37450000-37475000~~chr21:37625000-37650000,
chr21:37475000-37500000~~chr21:37625000-37650000,
chr21:37500000-37525000~~chr21:37625000-37650000,
chr21:37525000-37550000~~chr21:37625000-37650000,