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Basic information

CohesinDB ID: CDBP00418950

Locus: chr21-37636032-37637375

Data sourse: GSE206145-GSE177045, ENCSR501LQA, ENCSR150EFU, GSE25021, ENCSR330ELC, GSE165895, GSE115602, GSE138405, GSE101921, GSE206145-NatGen2015, ENCSR703TNG, ENCSR199XBQ, ENCSR193NSH, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR495WGO, ENCSR853VWZ, ENCSR956LGB, ENCSR335RKQ, ENCSR537EFT, ENCSR153HNT, GSE68388, ENCSR748MVX

Cell type: MCF-7, RPE, HMEC, Fibroblast, Hela-Kyoto, A-549, K-562, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 11% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 95% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 36%, "14_ReprPCWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, CHD8, SMC1A, FOXA2, POU2F2, SIN3A, ZFX, STAG2, XBP1, SMAD3, FOXA1, KDM1A, RELA, CREBBP, JUNB, ATF3, RUNX2, MYC, GATA4, NEUROD1, MCM3, PBX4, HIF1A, ARNT, DAXX, ZNF532, HMGB2, GATA3, MAF1, STAT3, TP63, SMARCE1, ZNF143, FOS, MAX, TAL1, NRIP1, MED1, DNMT3B, NR3C1, CEBPB, ZNF750, NCOA3, TEAD1, NR2F2, KLF6, SNAI2, CREB1, TFAP2C, NEUROG2, TP53, ESR1, OCA2, GRHL2, TBX5, ELF3, TCF12, JUN, SP1, EP300, ARRB1, EHF, AR, IRF1, TFAP2A, NUTM1, SOX4, YAP1, REST, GATA2, EGLN2, ZNF548, BRD4, JUND, E2F1, SMC3, STAG1, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): TTC3,VPS26C,KCNJ6,HLCS,DYRK1A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

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Deatailed information for cohesin site CDBP00418950