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Basic information

CohesinDB ID: CDBP00418952

Locus: chr21-37641601-37643989

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE93080, GSE67783, GSE86191, GSE101921, GSE51234, GSE112028, GSE130135, ENCSR199XBQ, ENCSR895JMI, ENCSR000EEG, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE131577, GSE104888, GSE126634, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE110061, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR879KXD, ENCSR000BLS, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: RH4, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, GP5d, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, GM18505, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HCAEC, GM19238, HeLa, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 51% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.367

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 95% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 39%, "15_Quies": 38%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: ZSCAN5C, XBP1, FOXA1, HDGF, BMI1, CTCFL, ZNF444, ZNF532, PAX5, ZSCAN4, ELF1, TRIM28, ETV1, NFE2L2, ESR1, CTCF, TCF12, JUN, E4F1, NUTM1, DPF2, E2F6, IRF4, SMC1, EHMT2, TFAP2C, GLIS1, POU2F2, CHD8, POU5F1, MYCN, TOP2A, CTBP1, ZBTB48, SRF, NBN, MYC, SMARCA4, RAD21, GRHL3, RXRA, NKX2-1, FOXK2, XRCC5, PRDM14, IKZF1, RCOR1, EZH2, FEZF1, ZHX2, HES1, GATA2, ZNF644, ZSCAN29, DRAP1, SMARCA5, ETV5, CC2D1A, SMC1A, NKX2-2, ZFX, SMAD3, ZNF654, ERG3, TRIM22, ZBTB2, BRD9, ARNT, ATF2, PRDM9, ZNF518A, ZEB2, HMBOX1, CBFA2T3, CDK8, MED1, TEAD3, TERF1, SMAD1, NCOA1, L3MBTL2, NIPBL, REST, ZHX1, FOXP1, SMC3, MLLT1, STAG1, STAG2, NFATC3, FOXA2, CBX3, GTF2B, YY2, KDM1A, YY1, RELA, TARDBP, NEUROD1, ZFP36, HIF1A, TAL1, MAX, ZNF143, MTA1, KLF4, SP7, GFI1B, KDM5B, TP53, ZNF334, BRD2, ELF3, BHLHE40, RXR, RB1, HSF1, RNF2, BRD4, ILF3, JUND, SCRT1, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): HLCS,TTC3,KCNJ6,DYRK1A,VPS26C

Function elements

Human SNPs: .

Number of somatic mutations (coding): 40

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418952