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Basic information

CohesinDB ID: CDBP00418955

Locus: chr21-37647564-37648424

Data sourse: GSE67783, GSE111913, GSE101921, GSE85526, GSE206145-NatGen2015, ENCSR153HNT

Cell type: HMEC, Fibroblast, HEKn, RT-112, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 95% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 42%, "15_Quies": 37%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SOX2, HNF1A, XBP1, FOXA1, PBX2, BMI1, CHD7, PRDM1, ZNF532, MECOM, PAX5, TP63, HDAC3, SNAI2, ESR1, JUN, CTCF, BAF155, EP300, NUTM1, E2F1, ZNF528, SMC1, TEAD4, PDX1, TFAP2C, NANOG, CHD8, POU2F2, BRD1, POU5F1, ZNF263, MYCN, ZBTB48, DUX4, STAT1, ZSCAN5A, DDX5, HNF4G, ERG, OGG1, ETS1, MYC, MCM5, SMARCA4, RAD21, GRHL3, PROX1, GABPA, STAT3, NKX3-1, RCOR1, NR3C1, ZNF750, EZH2, GRHL2, EBF3, TRPS1, EHF, HDAC2, GATA2, FLI1, NCOA2, RUNX1, BCL6, SMC1A, NKX2-2, ZFX, SMAD3, ZNF770, CBX8, ERG3, PRDM10, CREBBP, ZNF384, RUNX2, GR, PBX4, ARNT, DAXX, NRF1, HMGB2, ATF2, FOS, MED1, ZMYM3, PIAS1, NIPBL, SP1, TFAP2A, ARID1A, ATF7, ASH2L, BCOR, FOXP1, SMC3, STAG1, STAG2, PAX7, TRP47, CBFA2T2, MEF2B, PPARG, GTF2B, WT1, HOXB13, KDM1A, YY1, RELA, JUNB, NEUROD1, ZNF266, MCM3, SP140, ZFP36, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, GATA1, ZNF143, CBX2, TLE3, NCOA3, NR2F2, TP53, PKNOX1, NFKB1, AR, RNF2, NOTCH3, BRD4, JUND, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): VPS26C,TTC3,KCNJ6,DYRK1A,HLCS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 10

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418955