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Basic information

CohesinDB ID: CDBP00418957

Locus: chr21-37654485-37655372

Data sourse: GSE67783, GSE86191, GSE98367, GSE138405, GSE206145, GSE120943, ENCSR153HNT

Cell type: RPE, Hela-Kyoto, HCT-116, Monocytes, K-562, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: NIPBL,SA1,Rad21,SMC1,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 95% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 47%, "15_Quies": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, FOSL1, NME2, XBP1, FOXA1, PBX2, ZNF596, ATF3, CTCFL, RUNX3, ZNF532, MORC2, ZNF189, ZSCAN4, TP63, HDAC3, TEAD1, ELF1, KLF6, SNAI2, NFE2L2, RBM39, ESR1, HNF1B, HDAC8, CTCF, JUN, BAF155, NUTM1, EP300, MNT, KLF1, E2F6, TRIM24, SMC1, TEAD4, PDX1, TFAP2C, EED, POU2F2, CHD8, ZSCAN5D, ZNF263, MYCN, POU5F1, TOP2A, CTBP1, ZNF317, ZBTB48, ZSCAN5A, DUX4, STAT1, HNF4G, ERG, ETS1, MYC, SMARCA4, ARID1B, RAD21, GRHL3, PROX1, NKX2-1, FOXK2, RXRA, GABPA, STAT3, NKX3-1, PRDM14, IKZF1, NFE2, HNRNPH1, RCOR1, TERF2, NR2F6, NR3C1, ESRRA, CEBPB, HNRNPL, CREB1, EZH2, GRHL2, ZNF565, NFE2L1, SPI1, IRF1, GATA2, MXD3, RUNX1, ZNF585A, MAFG, SMC1A, HDAC1, NKX2-2, SIN3A, ZFX, SMAD3, TET2, ERG3, PRDM10, RARA, ZNF384, ZNF35, CREBBP, RUNX2, GATA4, GR, PBX4, ARNT, NRF1, BACH1, ATF2, PRDM9, ZEB2, HMGB2, SMARCB1, FOS, CDK8, MED1, TEAD3, PIAS1, ZNF3, C11orf30, L3MBTL2, SREBF2, MAFK, USF1, SP1, BCL11A, NR4A1, HNF4A, REST, ATF7, ASH2L, FOXP1, AATF, SMC3, STAG1, STAG2, PAX7, PPARG, TBL1X, FOXA2, MTA3, EBF1, WT1, MAFF, ESR2, FOXF1, CDK9, HOXB13, YY1, RELA, ZNF148, JUNB, NEUROD1, AHR, SP140, ZIC2, HIF1A, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, GATA1, PLAG1, CBX2, TLE3, NCOA3, NR2F2, NR2F1, KDM5B, TP53, ZNF334, NFKB1, BCL6B, MYOD1, ELF3, BHLHE40, AR, PAX3-FOXO1, EGLN2, RB1, HSF1, RNF2, BRD4, JUND, ILF3, MAZ, BRCA1, ZNF316

Target gene symbol (double-evidenced CRMs): DYRK1A,KCNJ6,HLCS,VPS26C,TTC3

Function elements

Human SNPs: Electroencephalographic_traits_in_alcoholism

Number of somatic mutations (coding): 14

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418957