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Basic information

CohesinDB ID: CDBP00418962

Locus: chr21-37665901-37666635

Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, GSE86191

Cell type: RPE, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 95% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 32%, "14_ReprPCWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, POU2F2, CHD8, PPARG, ZNF263, MYCN, SS18, ZFX, POU4F2, XBP1, ZBTB17, ZBTB48, SMAD3, ZSCAN5A, FOXA1, WT1, STAT1, ERG3, HOXB13, SMARCC1, ERG, KDM1A, RELA, YY1, ETS1, MYC, RUNX2, SMARCA4, OSR2, SP140, PBX4, HIF1A, ATF2, GABPA, TAL1, STAT3, NKX3-1, FOS, ZNF143, MED1, ZNF750, CEBPB, TRIM28, ETV1, PIAS1, ZMYM3, EZH2, ESR1, OCA2, GRHL2, SETDB1, EBF3, JUN, ELF3, CTCF, BAF155, AR, GATA2, REST, FLI1, ASH2L, RNF2, BRD4, ZNF528, SMC1, MAZ, SMC3

Target gene symbol (double-evidenced CRMs): KCNJ6,VPS26C,TTC3,HLCS,DYRK1A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418962