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Basic information

CohesinDB ID: CDBP00418963

Locus: chr21-37667425-37669249

Data sourse: ENCSR000BLD, GSE67783, GSE86191, GSE111913, GSE105028, GSE206145-NatGen2015, GSE206145, GSE97394, GSE64758

Cell type: RPE, H1-hESC, Fibroblast, HCT-116, HUES64, RT-112, HSPC, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: NIPBL,SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 95% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 39%, "14_ReprPCWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, TRIM25, SMC1A, BRD1, FOXA2, MYCN, ZSCAN5D, POU5F1, CHD8, ZFX, TOP2A, XBP1, SOX2, ZBTB48, WT1, ZSCAN5A, FOXA1, DUX4, ZNF134, MAFF, NME2, ERG, RELA, ZNF384, OGG1, ATF3, EZH1, MYC, SMARCA4, ZNF362, ZNF610, SP140, GRHL3, ARNT, RAD21, CHD7, CBFB, MORC2, STAT3, MAF1, MAX, PRDM14, GATA1, TEAD1, TRIM28, EZH2, ZNF3, ESR1, OCA2, MAFG, C11orf30, ZNF22, CTCF, NANOG, USF1, NIPBL, MAFK, GATA6, PAX8, RXR, ZBTB7A, E2F6, HEXIM1, FLI1, HSF1, NOTCH3, BRD4, MAZ, SMC3, ZNF316, STAG1, TFAP2C

Target gene symbol (double-evidenced CRMs): TTC3,VPS26C,DYRK1A,HLCS,KCNJ6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 38

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418963