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Basic information

CohesinDB ID: CDBP00418965

Locus: chr21-37673084-37677389

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388

Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, TC-71, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, THP-1, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, CNCC-WT33iPSC, BGO3, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 73% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.211

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 95% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 35%, "13_ReprPC": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, ZNF280D, XBP1, KDM4B, FOXA1, SUZ12, RBFOX2, PBX2, ZFHX2, KDM3A, HNRNPK, KDM4C, SIN3B, ZNF90, ATF3, THAP1, CTCFL, ZBTB44, CHD7, ZNF444, CBFB, PAX5, TP63, CDX2, JMJD1C, ZNF121, BCLAF1, RBM39, SNAI2, NFE2L2, KLF6, LMO2, ESR1, OCA2, TRIM28, HDAC8, ZFP91, ZNF524, CTCF, JUN, TCF12, EP300, BAF155, KLF1, RYBP, PAX8, E2F6, TRIM24, IRF4, E2F4, E2F1, ZNF528, SMC1, TEAD4, FOXA3, GTF2F1, TFAP2C, EED, JARID2, GLIS1, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, POU5F1, TOP2A, ZNF778, CDK7, CTBP1, ZNF263, ZBTB17, ZBTB48, ZSCAN5A, RUNX1T1, STAT1, NONO, SRF, ERG2, TBP, HOXC5, ERG, OGG1, MYC, EZH1, SMARCA4, ZNF2, KDM4A, RAD21, FOXP2, GRHL3, GABPA, STAT3, XRCC5, PRDM14, IKZF1, RCOR1, NFE2, DNMT3B, NR3C1, CEBPB, ESRRA, CREB1, EZH2, JMJD6, GABPB1, SPI1, MIXL1, HDAC2, GATA2, ZNF182, MXD3, FLI1, ZGPAT, SMARCA5, ZNF766, RUNX1, SMC1A, BCL6, CBX1, SIRT6, IRF3, NKX2-2, AFF4, ZFX, SIN3A, ZFP3, SMAD3, ZNF654, ERG3, ZNF770, TET2, TRIM22, ZBTB2, ZNF35, RARA, TAF15, CDK6, GR, PBX4, ARNT, BACH1, NRF1, ZBTB10, ATF2, PRDM9, ZNF48, SMAD4, ZNF708, TFDP1, NCAPH2, SMARCB1, CDK8, HMGXB4, MED1, GMEB1, TEAD3, ZEB1, SCRT2, PIAS1, SMAD1, MBD1, KLF16, USF1, BCL11A, SP1, GSPT2, HNF4A, REST, ZBTB7A, RBM25, ASH2L, HNRNPLL, PHIP, BCOR, FOXP1, AATF, ZNF623, SMC3, STAG1, STAG2, CXXC4, SKI, ZNF283, CBFA2T2, TRP47, FOXA2, MTA3, CREM, CHD2, RBBP5, TBL1X, AGO1, GTF2B, WT1, ZNF30, ZNF574, CDK9, HOXB13, ZNF580, KDM1A, YY1, RELA, TARDBP, NEUROD1, SP140, ZIC2, HIF1A, ZFP36, SKIL, PCGF1, BATF, MAX, NRIP1, ZNF143, CBX2, SP7, NCOA3, GFI1B, TCF7L2, NR2F1, KDM5B, TP53, NFKB1, EGR2, BRD2, ELF3, NANOG, RBM14, BHLHE40, AR, ARID4B, TAF1, RXR, ZNF324, EGLN2, ZBTB42, HEXIM1, RB1, TFIIIC, HSF1, RNF2, MYNN, SCRT1, BRD4, ILF3, ZBTB26, JUND, MAZ, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): TTC3,DYRK1A,VPS26C,HLCS,KCNJ6,PSMG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 48

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542, ENSG00000183527,

eachgene

Deatailed information for cohesin site CDBP00418965