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Basic information

CohesinDB ID: CDBP00418974

Locus: chr21-37709173-37709675

Data sourse: GSE206145, GSE67783, GSE68388

Cell type: RPE, HSPC, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 95% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 51%, "14_ReprPCWk": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, TRIM25, ZSCAN5C, SOX2, MEIS2, XBP1, PATZ1, FOXA1, HLF, SUZ12, PBX2, ZFHX2, TFAP4, HNRNPK, ZNF90, ATF3, HNRNPUL1, CTCFL, CHD7, PRDM1, RUNX3, ZNF444, ZNF189, MITF, ZNF467, MYOG, ZNF629, JMJD1C, TEAD1, TRIM28, BCLAF1, RBM39, NFE2L2, KLF10, ZNF624, ESR1, PITX3, ZNF561, ZFP91, CTCF, JUN, TCF12, EP300, BAF155, KLF1, MNT, DPF2, E2F6, TRIM24, RFX5, IRF4, DEK, PBX3, E2F1, SMC1, ZNF280A, TEAD4, FOXA3, GTF2F1, PDX1, TFAP2C, EED, GLIS1, NANOG, CHD8, POU2F2, ZSCAN5D, BRD3, MYCN, ZNF263, POU5F1, RUNX1T1, ZBTB17, ZBTB48, ZSCAN5A, STAT1, SRF, ERG2, ARID3A, SP4, TBP, HNF4G, ERG, PBX1, ASCL1, ZBTB8A, ETS1, MYC, NFKB2, SMARCA4, TSHZ1, RFX1, RAD21, FOXP2, GRHL3, RXRA, PROX1, STAT3, XRCC5, NKX3-1, CREM, ZNF398, NFE2, RCOR1, NR2F6, MIER3, NR3C1, ESRRA, CEBPB, KMT2A, CREB1, FOXK1, CCAR2, EZH2, JMJD6, FEZF1, EBF3, SPI1, IRF1, PCBP1, HDAC2, GATA2, SIX2, FLI1, HCFC1, NR2C2, MXI1, SMARCA5, MRTFB, MYF5, ETV5, CC2D1A, RUNX1, MAFG, BCL6, SMC1A, NKX2-2, EZH2phosphoT487, LDB1, AFF4, ZFX, ZNF534, SIN3A, SMAD3, PCBP2, TET2, CBX8, ERG3, ZNF654, NFXL1, TRIM22, TWIST1, SMARCC1, CREBBP, NFYC, ZNF35, ZBTB2, ZNF384, RUNX2, CDK6, GATA4, OSR2, ZNF184, DAXX, BACH1, NRF1, PBX4, SOX11, ZBTB10, ARNT, ZEB2, ZNF518A, ATF2, CBFA2T3, PRDM9, FOXJ2, MAFB, CDK8, CHD1, NFYA, HMGXB4, MED1, FOS, ZXDB, PIAS1, SMAD1, C11orf30, TBX5, STAT5A, KLF16, MAFK, SP1, USF1, BCL11A, HNF4A, NR4A1, CBX3, IKZF5, REST, OVOL3, RBM25, POU2F3, ZHX1, ASH2L, PHIP, TCF3, FOXP1, PRDM6, SMC3, ELL2, STAG1, STAG2, NFATC3, SKI, TRP47, MEF2B, PPARG, TBL1X, FOXA2, EBF1, CHD2, SS18, MEIS1, ZNF600, ZNF692, ZSCAN16, MAFF, WT1, GTF2B, FOXF1, ZNF574, CDK9, HOXB13, KDM1A, YY1, RELA, NEUROD1, AHR, ISL1, SP140, ZIC2, HIF1A, ZFP36, GATA3, BATF, MAX, NRIP1, ZNF143, HAND2, TLE3, ZFP69B, KLF4, SP7, GFI1B, NR2F2, ZNF512, NR2F1, NEUROG2, KDM5B, TP53, PKNOX1, NFKB1, MYOD1, EGR2, PHOX2B, BRD2, BHLHE40, AR, PAX3-FOXO1, EGLN2, ZBTB42, ZNF366, RB1, HSF1, RNF2, NOTCH3, BRD4, JUND, ZBTB26, CLOCK, ILF3, MAZ, TBX2, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): PSMG1,KCNJ6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157542, ENSG00000183527,

eachgene

Deatailed information for cohesin site CDBP00418974