- Basic information
- CohesinDB ID: CDBP00418988
- Locus: chr21-37757343-37761477
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, TC-71, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, BGO3, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 75% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.178
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 36%,
"15_Quies": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: GLIS1, ZSCAN5D, ZNF263, NKX2-2, FOXA2, ZFX, WT1, FOXA1, ERG3, ERG2, ZFHX2, PRDM10, ZBTB21, ASCL1, MYC, ZIC2, ARNT, MAX, NKX3-1, MED1, KLF4, EGR2, CTCF, SP1, KLF1, KLF17, ASH2L, BRD4, PDX1
- Target gene symbol (double-evidenced CRMs): KCNJ6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 70
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000157542,
- Related loop:
chr21:37750000-37775000~~chr21:37875000-37900000,
chr21:37750000-37775000~~chr21:37900000-37925000,
chr21:37750000-37775000~~chr21:38025000-38050000,
chr21:37750000-37775000~~chr21:38100000-38125000,
chr21:37750000-37775000~~chr21:38125000-38150000,
chr21:37750000-37775000~~chr21:38150000-38175000,
chr21:37750000-37775000~~chr21:38350000-38375000,
chr21:37757478-37760684~~chr21:37872980-37874819,
chr21:37757478-37760684~~chr21:37914851-37917797,
chr21:37757478-37760684~~chr21:38125761-38128067,
chr21:37757478-37760684~~chr21:38355287-38357113,
chr21:37758041-37760564~~chr21:37914870-37917976,
chr21:37758041-37760564~~chr21:38125790-38127981,
chr21:37758041-37760564~~chr21:38351388-38354007,
chr21:37758054-37760218~~chr21:38125818-38127945,
chr21:37758054-37760218~~chr21:38355149-38357340,
chr21:37758083-37760394~~chr21:38120483-38122671,
chr21:37758083-37760394~~chr21:38125791-38127988,
chr21:37758083-37760394~~chr21:38355275-38357287,
chr21:37758088-37760278~~chr21:37915411-37917551,
chr21:37758088-37760278~~chr21:38125754-38127987,
chr21:37758096-37760150~~chr21:38351797-38353501,
chr21:37758111-37760132~~chr21:37915589-37917624,
chr21:37758111-37760132~~chr21:38125778-38127688,
chr21:37758111-37760132~~chr21:38355258-38357082,
chr21:37758115-37760170~~chr21:38120552-38122290,
chr21:37758115-37760170~~chr21:38125779-38127948,
chr21:37758115-37760184~~chr21:37915273-37917670,
chr21:37758129-37760281~~chr21:37915255-37918377,
chr21:37758129-37760281~~chr21:38125791-38127926,
chr21:37758130-37760186~~chr21:37915343-37917688,
chr21:37758130-37760186~~chr21:38126066-38127958,
chr21:37758130-37760186~~chr21:38351811-38353488,
chr21:37758130-37760186~~chr21:38355272-38357307,
chr21:37758135-37760096~~chr21:37915636-37917622,
chr21:37758140-37760150~~chr21:37915315-37917747,
chr21:37758140-37760150~~chr21:38125798-38127942,
chr21:37758144-37760203~~chr21:37915295-37918332,
chr21:37758144-37760203~~chr21:38125941-38127948,
chr21:37758163-37760055~~chr21:38125763-38127934,
chr21:37758163-37760055~~chr21:38351823-38353474,
chr21:37758163-37760055~~chr21:38355110-38357173,
chr21:37758198-37760138~~chr21:37914884-37917576,
chr21:37758198-37760138~~chr21:38125801-38127928,
chr21:37758212-37760210~~chr21:37915283-37917809,
chr21:37758212-37760210~~chr21:38125779-38127911,
chr21:37758230-37760229~~chr21:37915529-37918394,
chr21:37758230-37760229~~chr21:38125749-38127915,
chr21:37758320-37760162~~chr21:37915283-37917707,
chr21:37758324-37760023~~chr21:37915309-37917693,
chr21:37758324-37760023~~chr21:38125804-38127970,
chr21:37758368-37760158~~chr21:37915292-37917676,
chr21:37758368-37760158~~chr21:38125770-38127709,
chr21:37758370-37760095~~chr21:38125971-38127690,
chr21:37758391-37760172~~chr21:38126009-38127637,
chr21:37758392-37760187~~chr21:38355277-38357273,
chr21:37758409-37759787~~chr21:37915637-37917611,
chr21:37758410-37759974~~chr21:38125958-38127687,
chr21:37758410-37760220~~chr21:38355384-38357279,
chr21:37758419-37759941~~chr21:38125927-38127658,
chr21:37758428-37759911~~chr21:38125778-38127949,
chr21:37758446-37759976~~chr21:38125725-38127860,
chr21:37758468-37759930~~chr21:38126131-38127619,
chr21:37758479-37759910~~chr21:38126125-38127630,
chr21:37758504-37759946~~chr21:38355473-38356966,
chr21:37758513-37759885~~chr21:38126191-38127689,
chr21:37758520-37759866~~chr21:38126208-38127589,
chr21:37758520-37759927~~chr21:38352107-38353483,
chr21:37758533-37759896~~chr21:38169685-38171409,
chr21:37758563-37759871~~chr21:38126251-38127506,