- Basic information
- CohesinDB ID: CDBP00418989
- Locus: chr21-37761722-37763591
-
Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE68388, GSE83726, GSE116344, GSE165895
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Cell type: RPE, Fibroblast, HCT-116, RH4, K-562, HSPC, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SA2,SMC1
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 40%,
"14_ReprPCWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, NME2, XBP1, FOXA1, SUZ12, KDM3A, ZBTB7B, HDGF, ATF3, BMI1, CTCFL, ZBTB5, ZNF444, ZNF189, ZSCAN4, TP63, ZNF736, CDC5L, ZNF121, BCLAF1, ETV1, SNAI2, ESR1, OCA2, HDAC8, CTCF, JUN, TCF12, KLF1, E4F1, MNT, RYBP, SOX4, TRIM24, GLI4, ZNF407, ZNF410, ZNF512B, ZNF776, E2F1, SMC1, TEAD4, PDX1, TFAP2C, EHMT2, PLRG1, JARID2, YBX1, POU2F2, NANOG, ZNF263, POU5F1, RUNX1T1, ID3, MYCN, CTBP1, ZNF239, TOP2A, ZBTB48, ZSCAN5A, STAT1, NONO, SRF, DDX5, PHB2, ERG, ASCL1, MYC, SMARCA4, RAD21, GRHL3, PROX1, GABPA, XRCC5, PRDM14, IKZF1, RCOR1, NFE2, ZNF639, NR3C1, ESRRA, CREB1, YBX3, EZH2, ARHGAP35, GABPB1, SPI1, HES1, MIXL1, IRF1, HDAC2, GATA2, SSRP1, GATAD2B, MXD3, FLI1, SMARCA5, NFIL3, MYF5, ETV5, RUNX1, SMC1A, HDAC1, NKX2-2, ZNF707, SIN3A, ZFX, SMAD3, ZNF770, TET2, NFXL1, ERG3, TRIM22, PRDM10, ZBTB2, NOTCH1, BRD9, RUNX2, CDK6, GATA4, ZNF184, NFIB, ARNT, SMAD4, PBX3, CHD1, CDK8, SUPT5H, MED1, ZEB1, SCRT2, SMAD1, NCOA1, USF1, BCL11A, GSPT2, PHF20, ARID2, REST, BCOR, FOXP1, SMC3, STAG2, STAG1, MLLT1, CBFA2T2, FOXA2, MTA3, EBF1, WT1, ZNF662, MEF2C, ZBTB33, ZNF580, ZKSCAN1, BCL3, KDM1A, YY1, RELA, TARDBP, NEUROD1, ZNF266, SP140, HIF1A, OTX2, ZNF311, GATA3, TAL1, MAX, ZNF143, GATA1, HAND2, ZNF592, NCOA3, NEUROG2, ZNF791, KDM5B, TP53, ZNF687, PKNOX1, MYOD1, BRD2, ELF3, AR, PAX3-FOXO1, EGLN2, RB1, ZBTB26, HSF1, BRD4, JUND, SCRT1, MAZ, TBX2, ZNF24
- Target gene symbol (double-evidenced CRMs): KCNJ6
- Function elements
- Human SNPs: Response_to_placebo_treatment_in_childhood_asthma_(FVC_change)
- Number of somatic mutations (coding): 24
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000157542,
- Related loop:
chr21:37750000-37775000~~chr21:37875000-37900000,
chr21:37750000-37775000~~chr21:37900000-37925000,
chr21:37750000-37775000~~chr21:38025000-38050000,
chr21:37750000-37775000~~chr21:38100000-38125000,
chr21:37750000-37775000~~chr21:38125000-38150000,
chr21:37750000-37775000~~chr21:38150000-38175000,
chr21:37750000-37775000~~chr21:38350000-38375000,
chr21:37757478-37760684~~chr21:37872980-37874819,
chr21:37757478-37760684~~chr21:37914851-37917797,
chr21:37757478-37760684~~chr21:38125761-38128067,
chr21:37757478-37760684~~chr21:38355287-38357113,
chr21:37758041-37760564~~chr21:37914870-37917976,
chr21:37758041-37760564~~chr21:38125790-38127981,
chr21:37758041-37760564~~chr21:38351388-38354007,
chr21:37758054-37760218~~chr21:38125818-38127945,
chr21:37758054-37760218~~chr21:38355149-38357340,
chr21:37758083-37760394~~chr21:38120483-38122671,
chr21:37758083-37760394~~chr21:38125791-38127988,
chr21:37758083-37760394~~chr21:38355275-38357287,
chr21:37758088-37760278~~chr21:37915411-37917551,
chr21:37758088-37760278~~chr21:38125754-38127987,
chr21:37758096-37760150~~chr21:38351797-38353501,
chr21:37758111-37760132~~chr21:37915589-37917624,
chr21:37758111-37760132~~chr21:38125778-38127688,
chr21:37758111-37760132~~chr21:38355258-38357082,
chr21:37758115-37760170~~chr21:38120552-38122290,
chr21:37758115-37760170~~chr21:38125779-38127948,
chr21:37758115-37760184~~chr21:37915273-37917670,
chr21:37758129-37760281~~chr21:37915255-37918377,
chr21:37758129-37760281~~chr21:38125791-38127926,
chr21:37758130-37760186~~chr21:37915343-37917688,
chr21:37758130-37760186~~chr21:38126066-38127958,
chr21:37758130-37760186~~chr21:38351811-38353488,
chr21:37758130-37760186~~chr21:38355272-38357307,
chr21:37758135-37760096~~chr21:37915636-37917622,
chr21:37758140-37760150~~chr21:37915315-37917747,
chr21:37758140-37760150~~chr21:38125798-38127942,
chr21:37758144-37760203~~chr21:37915295-37918332,
chr21:37758144-37760203~~chr21:38125941-38127948,
chr21:37758163-37760055~~chr21:38125763-38127934,
chr21:37758163-37760055~~chr21:38351823-38353474,
chr21:37758163-37760055~~chr21:38355110-38357173,
chr21:37758198-37760138~~chr21:37914884-37917576,
chr21:37758198-37760138~~chr21:38125801-38127928,
chr21:37758212-37760210~~chr21:37915283-37917809,
chr21:37758212-37760210~~chr21:38125779-38127911,
chr21:37758230-37760229~~chr21:37915529-37918394,
chr21:37758230-37760229~~chr21:38125749-38127915,
chr21:37758320-37760162~~chr21:37915283-37917707,
chr21:37758324-37760023~~chr21:37915309-37917693,
chr21:37758324-37760023~~chr21:38125804-38127970,
chr21:37758368-37760158~~chr21:37915292-37917676,
chr21:37758368-37760158~~chr21:38125770-38127709,
chr21:37758370-37760095~~chr21:38125971-38127690,
chr21:37758391-37760172~~chr21:38126009-38127637,
chr21:37758392-37760187~~chr21:38355277-38357273,
chr21:37758409-37759787~~chr21:37915637-37917611,
chr21:37758410-37759974~~chr21:38125958-38127687,
chr21:37758410-37760220~~chr21:38355384-38357279,
chr21:37758419-37759941~~chr21:38125927-38127658,
chr21:37758428-37759911~~chr21:38125778-38127949,
chr21:37758446-37759976~~chr21:38125725-38127860,
chr21:37758468-37759930~~chr21:38126131-38127619,
chr21:37758479-37759910~~chr21:38126125-38127630,
chr21:37758504-37759946~~chr21:38355473-38356966,
chr21:37758513-37759885~~chr21:38126191-38127689,
chr21:37758520-37759866~~chr21:38126208-38127589,
chr21:37758520-37759927~~chr21:38352107-38353483,
chr21:37758533-37759896~~chr21:38169685-38171409,
chr21:37758563-37759871~~chr21:38126251-38127506,