- Basic information
- CohesinDB ID: CDBP00418991
- Locus: chr21-37767377-37769076
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Data sourse: GSE206145-GSE177045, GSE72082, GSE111913, ENCSR000HPG, GSE76893, GSE206145-NatGen2015, GSE68388, ENCSR703TNG, GSE116344, GSE115602
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Cell type: MCF-7, Fibroblast, RH4, IMR-90, RT-112, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: NIPBL,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 47%,
"14_ReprPCWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NCOA2, PGR, FOXA2, NKX2-2, SRC, MYCN, SIN3A, ZFX, CTBP1, DUX4, SMAD3, ESR2, FOXA1, ERG, RELA, CREBBP, ZNF384, ASCL1, ZXDC, NEUROD1, JUNB, MYC, AHR, SMARCA4, RUNX2, RAD21, GRHL3, ARNT, OTX2, ATF2, GATA3, TAL1, MAX, PBX3, NRIP1, FOS, FOXM1, NKX3-1, HAND2, MED1, VDR, NR3C1, ESRRA, KLF4, NCOA3, NR2F2, TRIM28, TEAD1, CREB1, NEUROG2, SCRT2, EZH2, ZNF217, ESR1, PKNOX1, OCA2, NCOA1, GRHL2, JUN, TCF12, EP300, NIPBL, TFAP2A, AR, ZNF257, ZSCAN2, HDAC2, MED12, BRD4, CTBP2, MBD2, SCRT1, E2F1, ZNF350, ZNF440, SMC3, TFAP2C, FOSL2
- Target gene symbol (double-evidenced CRMs): KCNJ6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 30
- Number of somatic mutations (non-coding): 0
- Related genes and loops