- Basic information
- CohesinDB ID: CDBP00419006
- Locus: chr21-37817250-37818781
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Data sourse: ENCSR000EFJ, GSE98367, GSE138405, ENCSR404BPV, GSE206145, GSE206145-NatGen2015, GSE135093, GSE120943, ENCSR198ZYJ, GSE165895
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Cell type: RPE, Hela-Kyoto, Fibroblast, Monocytes, Neurons-H1, IMR-90, Macrophage, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 52%,
"7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, ZNF697, SOX2, XBP1, FOXA1, CHD7, PRDM1, PAX5, ZSCAN4, ZNF506, TEAD1, TRIM28, ESR1, OCA2, CTCF, TCF12, EP300, PAX8, PDX1, POU2F2, CHD8, NANOG, ZNF263, MYCN, POU5F1, KDM4C, TOP2A, ZBTB48, ZSCAN5A, STAT1, DDX5, TBP, ERG, MYC, RAD21, GRHL3, GABPA, STAT3, RCOR1, NR3C1, EZH2, ZHX2, SPI1, HDAC2, SIX2, FLI1, SMARCA5, ZNF490, RUNX1, SMC1A, NKX2-2, EZH2phosphoT487, AFF4, ZFX, POU4F2, CBX8, ZNF384, NOTCH1, BRD9, RUNX2, CDK6, NRF1, ARNT, PRDM9, MAFB, MED1, TERF1, MYB, ZMYM3, USF1, REST, RBM25, BCOR, FOXP1, SMC3, STAG1, PPARG, FOXA2, WT1, MEF2C, HOXB13, KDM1A, YY1, RELA, SP140, ZFP36, HIF1A, GATA3, ZNF143, GATA1, CBX2, NR2F1, ZNF768, NEUROG2, TP53, ZNF334, MYOD1, BHLHE40, AR, YAP1, NOTCH3, BRD4, MAZ, ADNP, AHR
- Target gene symbol (double-evidenced CRMs): ERG,KCNJ6
- Function elements
- Human SNPs: Smoking_initiation_(ever_regular_vs_never_regular)_(MTAG)
- Number of somatic mutations (coding): 30
- Number of somatic mutations (non-coding): 0
- Related genes and loops