- Basic information
- CohesinDB ID: CDBP00419015
- Locus: chr21-37848590-37851352
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Data sourse: ENCSR000EFJ, ENCSR853VWZ, ENCSR501LQA, GSE206145, GSE85526, GSE206145-NatGen2015, GSE68388, GSE116344, GSE165895
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Cell type: RPE, Fibroblast, RH4, HEKn, A-549, IMR-90, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 8% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 42%,
"7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, PGR, CHD8, SMC1A, CEBPA, MYCN, ZNF496, SIN3A, ZFX, POU4F2, TEAD4, CTBP1, SMAD3, MAFF, ESR2, STAT1, SRF, PBX2, SMARCC1, YY1, RELA, ETS1, RUNX2, CDK6, SMARCA4, CHD7, RAD21, GRHL3, HIF1A, PBX4, RXRA, STAT3, MAX, GATA1, FOS, MITF, CDK8, ZNF143, MED1, PLAG1, RCOR1, NR3C1, CEBPB, MYOG, NCOA3, TEAD1, TRIM28, MYB, ETV1, EZH2, KDM5B, ESR1, TP53, GRHL2, USF2, MYOD1, JUN, CTCF, USF1, SPI1, TCF12, MAFK, AR, PAX8, GATA2, YAP1, FLI1, HSF1, RAD51, BRD4, ZNF528, MAZ, MRTFB, NCOA2, KMT2B, MYF5, FOSL2
- Target gene symbol (double-evidenced CRMs): BRWD1,HLCS,ETS2,PSMG1,VPS26C,KCNJ6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 14
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159267,
ENSG00000157538,
ENSG00000157542,
ENSG00000157557,
ENSG00000183527,
ENSG00000185658,
- Related loop:
chr21:36975000-37000000~~chr21:37850000-37875000,
chr21:37250000-37275000~~chr21:37850000-37875000,
chr21:37700000-37725000~~chr21:37825000-37850000,
chr21:37825000-37850000~~chr21:37950000-37975000,
chr21:37825000-37850000~~chr21:38050000-38075000,
chr21:37850000-37875000~~chr21:37950000-37975000,
chr21:37850000-37875000~~chr21:38325000-38350000,
chr21:37850000-37875000~~chr21:38775000-38800000,
chr21:37850000-37875000~~chr21:38800000-38825000,
chr21:37850000-37875000~~chr21:39175000-39200000,