- Basic information
- CohesinDB ID: CDBP00419017
- Locus: chr21-37854587-37856602
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Data sourse: ENCSR000EFJ, GSE67783, ENCSR000HPG, GSE206145, GSE206145-NatGen2015, GSE135093, GSE83726, GSE116344, GSE165895
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Cell type: RPE, Fibroblast, RH4, IMR-90, HSPC, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 43%,
"7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: GLIS1, CHD8, FOXA2, POU5F1, EBF1, MYCN, SOX2, ZFX, POU4F2, NKX2-2, SMAD3, WT1, FOXA1, FOXF1, ERG3, HMGB1, YY1, RELA, ASCL1, NEUROD1, ATF3, RUNX2, MYC, SMARCA4, CDK6, CHD7, RAD21, SP140, GRHL3, OTX2, HMGB2, MAX, NKX3-1, FOS, CDK8, RCOR1, SNRNP70, MED1, CBX2, NR3C1, CEBPB, MYOG, PDX1, ETV1, NEUROG2, NFE2L2, EZH2, ESR1, MYOD1, JUN, ZHX2, MAFK, CTCF, BHLHE40, AR, SOX4, FLI1, ZNF777, NOTCH3, BRD4, ZNF490, MAZ, SMC3, MYF5, STAG1, FOSL2
- Target gene symbol (double-evidenced CRMs): PSMG1,ETS2,VPS26C,HLCS,KCNJ6,BRWD1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 18
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159267,
ENSG00000157538,
ENSG00000157542,
ENSG00000157557,
ENSG00000183527,
ENSG00000185658,
- Related loop:
chr21:36975000-37000000~~chr21:37850000-37875000,
chr21:37250000-37275000~~chr21:37850000-37875000,
chr21:37700000-37725000~~chr21:37825000-37850000,
chr21:37825000-37850000~~chr21:37950000-37975000,
chr21:37825000-37850000~~chr21:38050000-38075000,
chr21:37850000-37875000~~chr21:37950000-37975000,
chr21:37850000-37875000~~chr21:38325000-38350000,
chr21:37850000-37875000~~chr21:38775000-38800000,
chr21:37850000-37875000~~chr21:38800000-38825000,
chr21:37850000-37875000~~chr21:39175000-39200000,