- Basic information
- CohesinDB ID: CDBP00419020
- Locus: chr21-37863574-37864405
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Data sourse: GSE126755, GSE120943, GSE98367
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Cell type: Neutrophil, Monocytes, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: SMC3,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 70%,
"14_ReprPCWk": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, CEBPA, CREM, ZFX, SMAD3, STAT1, HOXB13, ZBTB21, RELA, ZNF384, JUNB, ATF3, ATF2, BATF3, BATF, MAX, FOS, CDK8, MITF, RCOR1, ZNF629, CEBPB, KMT2A, NEUROG2, USF2, MYOD1, JUN, TCF12, BCL11A, SPI1, BHLHE40, RFX5, ATF7, FLI1, BRD4, JUND, TCF3, E2F1, FOSL2
- Target gene symbol (double-evidenced CRMs): BRWD1,KCNJ6,VPS26C,PSMG1,HLCS,ETS2
- Function elements
- Human SNPs: Metabolite_levels
- Number of somatic mutations (coding): 8
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159267,
ENSG00000157538,
ENSG00000157542,
ENSG00000157557,
ENSG00000183527,
ENSG00000185658,
- Related loop:
chr21:36975000-37000000~~chr21:37850000-37875000,
chr21:37250000-37275000~~chr21:37850000-37875000,
chr21:37850000-37875000~~chr21:37950000-37975000,
chr21:37850000-37875000~~chr21:38325000-38350000,
chr21:37850000-37875000~~chr21:38775000-38800000,
chr21:37850000-37875000~~chr21:38800000-38825000,
chr21:37850000-37875000~~chr21:39175000-39200000,