- Basic information
- CohesinDB ID: CDBP00419022
- Locus: chr21-37865868-37866779
-
Data sourse: GSE98367, GSE120943, ENCSR153HNT, GSE111537, GSE126755
-
Cell type: Monocytes, Neutrophil, K-562, OCI-AML-3, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 58%,
"14_ReprPCWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: RUNX1, SKI, PGR, SMC1A, BCL6, CEBPA, CHD8, NME2, ZFX, MTA2, STAT1, ERG3, MEF2C, SUZ12, CDK9, ZKSCAN1, ERG, KDM1A, RELA, MYC, RAD21, MECOM, TAL1, MAFB, SPIB, FOS, CDK8, IKZF1, NFE2, BACH2, VDR, MED1, JMJD1C, CEBPB, MAF, ZEB1, TRIM28, MYB, KMT2A, EZH2, ESR1, MLL, C11orf30, GRHL2, CTCF, SPI1, BCL11A, TBX21, PAX3-FOXO1, ZBTB16, DPF2, RXR, PAX8, TRIM24, IRF4, ATF7, IKZF2, BRD4, KMT2B
- Target gene symbol (double-evidenced CRMs): HLCS,VPS26C,PSMG1,ETS2,KCNJ6,BRWD1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 14
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159267,
ENSG00000157538,
ENSG00000157542,
ENSG00000157557,
ENSG00000183527,
ENSG00000185658,
- Related loop:
chr21:36975000-37000000~~chr21:37850000-37875000,
chr21:37250000-37275000~~chr21:37850000-37875000,
chr21:37850000-37875000~~chr21:37950000-37975000,
chr21:37850000-37875000~~chr21:38325000-38350000,
chr21:37850000-37875000~~chr21:38775000-38800000,
chr21:37850000-37875000~~chr21:38800000-38825000,
chr21:37850000-37875000~~chr21:39175000-39200000,