- Basic information
- CohesinDB ID: CDBP00419023
- Locus: chr21-37868675-37872241
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Data sourse: ENCSR501LQA, ENCSR760NPX, ENCSR330ELC, GSE165895, ENCSR000EFJ, GSE206145-NatGen2015, ENCSR806UKK, ENCSR199XBQ, ENCSR895JMI, ENCSR768DOX, GSE206145, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR000HPG, ENCSR676MJK, ENCSR335RKQ, ENCSR537EFT, ENCSR153HNT, GSE68388, ENCSR748MVX
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Cell type: RPE, Fibroblast, HEKn, A-549, IMR-90, K-562, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 14% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 44%,
"7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, SMC1A, FOXA2, ZSCAN5D, NKX2-2, MYCN, SOX2, ZFX, EBF1, ZBTB17, SMAD3, ZBTB48, FOXA1, FOXF1, PBX2, RELA, ASCL1, JUNB, ATF3, RUNX2, NEUROD1, SMARCA4, MYC, GR, ARNT, PBX4, OTX2, GATA3, PRDM9, STAT3, MAX, FOS, RCOR1, HAND2, MED1, ZNF750, CEBPB, NR3C1, ETV1, NEUROG2, EZH2, ESR1, ZBTB6, PKNOX1, GRHL2, JUN, TFAP2A, AR, GATA2, BRD4, MAZ, TEAD4, ZNF554, TFAP2C, FOSL2
- Target gene symbol (double-evidenced CRMs): HLCS,ETS2,VPS26C,PSMG1,BRWD1,KCNJ6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 48
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159267,
ENSG00000157538,
ENSG00000157542,
ENSG00000157557,
ENSG00000183527,
ENSG00000185658,
- Related loop:
chr21:36975000-37000000~~chr21:37850000-37875000,
chr21:37250000-37275000~~chr21:37850000-37875000,
chr21:37700000-37725000~~chr21:37875000-37900000,
chr21:37725000-37750000~~chr21:37875000-37900000,
chr21:37750000-37775000~~chr21:37875000-37900000,
chr21:37757478-37760684~~chr21:37872980-37874819,
chr21:37775000-37800000~~chr21:37875000-37900000,
chr21:37850000-37875000~~chr21:37950000-37975000,
chr21:37850000-37875000~~chr21:38325000-38350000,
chr21:37850000-37875000~~chr21:38775000-38800000,
chr21:37850000-37875000~~chr21:38800000-38825000,
chr21:37850000-37875000~~chr21:39175000-39200000,
chr21:37873271-37874436~~chr21:38355282-38357170,
chr21:37875000-37900000~~chr21:38350000-38375000,