- Basic information
- CohesinDB ID: CDBP00419027
- Locus: chr21-37878690-37879785
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Data sourse: ENCSR501LQA, ENCSR760NPX, ENCSR150EFU, ENCSR330ELC, ENCSR000BUC, GSE165895, ENCSR000EFJ, GSE138405, GSE206145-NatGen2015, GSE120943, ENCSR199XBQ, GSE116344, ENCSR895JMI, GSE98367, ENCSR193NSH, GSE206145, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR676MJK, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, GSE68388, ENCSR748MVX
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Cell type: RPE, Macrophage, Fibroblast, Hela-Kyoto, Monocytes, HEKn, RH4, A-549, HeLa-S3, IMR-90, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 11% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.867
- Subunit: Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 44%,
"14_ReprPCWk": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, ZNF195, LCORL, ZNF660, E2F7, FOXA1, TFAP4, ZNF112, NFIC, CHD7, KLF14, TP63, TEAD1, TRIM28, ZNF624, ESR1, OCA2, ZIK1, CTCF, JUN, E2F6, TRIM24, ZNF528, ZNF350, TEAD4, ZNF263, MYCN, ZSCAN21, ZBTB17, ZNF300, MYC, RAD21, BATF3, STAT3, ZNF398, RCOR1, VDR, NR3C1, CEBPB, EZH2, GRHL2, ZHX2, RUNX1, BCL6, SMC1A, NKX2-2, ZFX, SMAD3, RUNX2, OSR2, ZNF184, NFIB, PBX4, SOX11, ARNT, PRDM9, CBFA2T3, FOS, CDK8, MED1, SCRT2, PIAS1, SMAD1, USF1, NIPBL, MAFK, SP1, SMC3, ZNF316, FOXA2, MEIS1, ZNF692, WT1, YY1, RELA, JUNB, MAX, ZSCAN26, ZNF143, KLF4, ZNF544, BCL6B, NFKB1, PHOX2B, BRD2, BHLHE40, AR, YAP1, BRD4, JUND, BRCA1, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): KCNJ6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 16
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000157542,
- Related loop:
chr21:36975000-37000000~~chr21:37850000-37875000,
chr21:37250000-37275000~~chr21:37850000-37875000,
chr21:37700000-37725000~~chr21:37875000-37900000,
chr21:37725000-37750000~~chr21:37875000-37900000,
chr21:37750000-37775000~~chr21:37875000-37900000,
chr21:37757478-37760684~~chr21:37872980-37874819,
chr21:37775000-37800000~~chr21:37875000-37900000,
chr21:37850000-37875000~~chr21:37950000-37975000,
chr21:37850000-37875000~~chr21:38325000-38350000,
chr21:37850000-37875000~~chr21:38775000-38800000,
chr21:37850000-37875000~~chr21:38800000-38825000,
chr21:37850000-37875000~~chr21:39175000-39200000,
chr21:37873271-37874436~~chr21:38355282-38357170,
chr21:37875000-37900000~~chr21:38350000-38375000,