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Basic information

CohesinDB ID: CDBP00419039

Locus: chr21-37913354-37918438

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE126755, ENCSR748MVX, GSE131577, ENCSR000BLD, GSE126634, GSE103477, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE25021, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, ENCSR000HPG, GSE111913, ENCSR335RKQ, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM2610, CVB-hiPSC, HSPC, CVI-hiPSC, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, THP-1, GM12890, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, HUES9, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, BGO3, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 62% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.333

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 68% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "13_ReprPC": 25%, "14_ReprPCWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, CBX5, ZNF660, E2F7, SOX2, HMGN3, PATZ1, FOXA1, SUZ12, RING1B, UBTF, PBX2, ZFHX2, ATF3, BMI1, ZNF362, CTCFL, CHD7, PRDM1, KLF14, CBFB, EGR1, MXD4, ZNF189, SMARCE1, MECOM, ZSCAN4, TP63, ZNF629, ELF1, TRIM28, ZNF121, RBM39, SNAI2, KLF6, ETV1, SAP30, ESR1, OCA2, NFE2L2, ZNF561, CTCF, TCF12, JUN, EP300, BAF155, KLF1, RYBP, SOX4, E2F6, PRDM4, IRF4, TRIM24, E2F1, ZNF528, SMC1, TEAD4, GTF2F1, EHMT2, TFAP2C, EED, PDX1, GLIS1, JARID2, NANOG, CHD8, BRD1, ZSCAN5D, ZNF263, POU5F1, MYCN, RUNX1T1, TOP2A, CTBP1, ZNF317, ZBTB17, ZBTB48, ZSCAN21, ZSCAN5A, DUX4, STAT1, ZNF134, SRF, DDX5, HIC1, ERG2, SP4, TBP, ERG, ZBTB21, MIER1, OGG1, ZBTB8A, MYC, ZNF25, SMARCA4, KDM4A, RFX1, RAD21, ZNF2, GRHL3, NKX2-1, GABPA, STAT3, XRCC5, NKX3-1, ZNF398, PRDM14, RCOR1, NFE2, NR3C1, CEBPB, SRSF3, CREB1, EZH2, KLF8, JMJD6, GABPB1, ZHX2, SPI1, KLF17, PCBP1, HDAC2, GATA2, ZNF182, ZBTB14, GATAD2B, MXD3, SIX2, FLI1, GTF3C5, ZGPAT, MXI1, HCFC1R1, NCOA2, ZNF554, RUNX1, THAP11, SMC1A, CBX1, EZH2phosphoT487, NKX2-2, SIRT6, SIN3A, ZFX, ZNF335, AFF4, SMAD3, ZBTB12, ZNF654, ERG3, NMYC, ZNF770, SMARCC1, PRDM10, TWIST1, ZNF18, RARA, ZNF384, ZNF35, ZNF133, TAF15, ZBTB2, RUNX2, IRF2, GATA4, ZNF184, SP3, ARNT, BACH1, TFDP1, ZBTB10, CBX3, ZNF48, NRF1, ZEB2, SMAD4, PBX4, NCAPH2, ZNF10, CHD1, SP2, HMGXB4, FOS, MED1, ZEB1, SPDEF, KDM6B, MYB, SCRT2, ZNF331, PIAS1, SMAD1, ZNF3, KLF9, L3MBTL2, KLF16, USF1, BCL11A, TFAP2A, SP1, ARID2, REST, ZBTB7A, IKZF5, CCNT2, POU2F3, ASH2L, HNRNPLL, CTBP2, AFF1, GLIS2, BCOR, FOXP1, PCGF2, AATF, MBD2, SMC3, PHIP, STAG1, STAG2, ZNF394, TRP47, AGO1, FOXA2, RBBP5, TBL1X, CHD2, CREM, MIER2, ZNF692, ZNF600, WT1, ZNF574, CDK9, ZNF580, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, ZNF441, TARDBP, JUNB, TEAD1, ZNF282, SP140, ZIC2, HIF1A, PCGF1, GATA3, TAL1, MAX, ZNF449, ZNF143, GATA1, HAND2, CBX2, KLF4, BCL11B, SP7, ZFP69B, GFI1B, ZNF512, NR2F1, NEUROG2, KDM5B, TP53, MYOD1, EGR2, PHOX2B, T, BRD2, BHLHE40, AR, TAF1, RXR, EGLN2, ZNF366, HEXIM1, ZNF280D, TFIIIC, HSF1, ZBTB26, RNF2, BRD4, SCRT1, JUND, RB1, ILF3, MAZ, TBX2, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): TTC3,VPS26C,HLCS,DYRK1A,KCNJ6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 111

Number of somatic mutations (non-coding): 11

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00419039