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Basic information

CohesinDB ID: CDBP00419073

Locus: chr21-38052709-38053305

Data sourse: GSE25021, GSE120943, GSE67783, GSE98367

Cell type: MCF-7, Monocytes, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 69% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 63%, "14_ReprPCWk": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: GLIS1, POU2F2, ZNF263, ZSCAN5C, ZNF778, ZFX, XBP1, ZNF692, ZBTB48, WT1, ZSCAN5A, ZBTB17, ZNF317, TET2, ERG3, SUZ12, ZNF30, ERG2, YY2, ZNF574, ZFHX2, ZNF18, HOXB13, YY1, RELA, FOXA1, ZNF35, OGG1, MYC, SMARCA4, TSHZ1, OSR2, ZNF610, SP140, ZIC2, ARNT, ATF2, ZEB2, ZNF189, MAX, ZSCAN4, ZNF143, SUPT5H, ZNF320, MED1, CEBPB, CREB1, ZNF680, EZH2, ESR1, OCA2, BMPR1A, ZNF334, ZSCAN22, ZNF561, EGR2, KLF16, CTCF, BRD2, GSPT2, AR, ZNF257, GATA2, ZNF324, ZBTB42, SIX2, ATF7, JUND, PHIP, ZNF423, BRD4, RELB, MAZ, ZNF528, SMC3, STAG1

Target gene symbol (double-evidenced CRMs): KCNJ6,ERG

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 8

Related genes and loops

Related gene: ENSG00000157542, ENSG00000157554,

eachgene

Deatailed information for cohesin site CDBP00419073