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Basic information

CohesinDB ID: CDBP00419075

Locus: chr21-38075842-38076104

Data sourse: GSE120943, GSE98367

Cell type: Monocytes, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 69% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 72%, "14_ReprPCWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFATC3, NFIA, PGR, CHD8, HDAC1, NME2, ZFX, MTA2, FOXA1, ZBTB33, SUZ12, ZNF823, PHB2, HOXB13, ZNF596, ZKSCAN1, ZFHX2, MLL4, RELA, CREBBP, ZBTB2, HDGF, TFAP4, EHMT2, BMI1, NFIC, SMARCA4, RFX1, ZNF184, ARID1B, ZBTB5, NFIB, ZNF444, ARNT, ZNF521, OSR2, PROX1, CHD7, GRHL3, SMARCE1, SUPT5H, IKZF1, MTA1, ZNF639, BCLAF1, ZNF512, ZNF544, ZNF791, SMAD1, ZNF687, PKNOX1, ARHGAP35, NCOA1, TP53, ESR1, GABPB1, TCF12, AR, DPF2, ZBTB40, HDAC2, ARID2, GATAD2B, ZNF366, SOX6, HSF1, RNF2, BRD4, SMARCA5, BCOR, ZNF24, MLLT1

Target gene symbol (double-evidenced CRMs): KCNJ6,ERG,DYRK1A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157540, ENSG00000157542, ENSG00000157554,

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Deatailed information for cohesin site CDBP00419075