- Basic information
- CohesinDB ID: CDBP00419089
- Locus: chr21-38120402-38123879
-
Data sourse: ENCSR000BTQ, GSE206145-GSE177045, GSE143937, GSE67783, ENCSR000BKV, GSE72082, ENCSR000EGW, ENCSR879KXD, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE68388, ENCSR703TNG
-
Cell type: MCF-7, RPE, Fibroblast, K-562, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
69% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 46%,
"14_ReprPCWk": 40%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOSL1, PGR, MEIS2, XBP1, FOXA1, SUZ12, RBFOX2, PBX2, UBTF, SIN3B, HDGF, ATF3, NFIC, HNRNPUL1, ATF4, SMARCE1, MITF, ELF1, TRIM28, TEAD1, ETV1, RBM39, NFE2L2, SMAD5, ESR1, SAP30, OCA2, HDAC8, CTCF, JUN, EP300, E4F1, MNT, GATA6, DPF2, TRIM24, RFX5, SOX6, E2F4, DDX20, E2F1, TEAD4, GTF2F1, PDX1, TFAP2C, EHMT2, EED, POU2F2, CHD8, POU5F1, ID3, CTBP1, MTA2, ASH1L, ZBTB48, DUX4, STAT1, ZSCAN5A, NONO, NBN, ARID3A, TBP, PAX6, ERG, MIER1, SMARCC2, MYC, SMARCA4, ARID1B, GRHL3, FOXK2, XRCC5, IKZF1, RCOR1, LEF1, DACH1, NFRKB, NR2F6, NR3C1, CEBPB, ESRRA, ZNF750, CREB1, ZBTB11, EZH2, TBL1XR1, GABPB1, PHF8, ELF4, SPI1, IRF1, ZNF257, HDAC2, GATA2, ZSCAN29, TAF9B, SREBF1, FLI1, HCFC1, NR2C2, MXI1, SMARCA5, EP400, NFYB, MYF5, ATF1, CC2D1A, HDAC1, EZH2phosphoT487, NKX2-2, SIN3A, ZFX, SMAD3, ZMIZ1, IRF2, ZNF384, ZBTB2, BRD9, RUNX2, ARNT, NRF1, TFDP1, PBX4, ATF2, HMBOX1, ZEB2, NFYA, FOXM1, SP2, CHD1, SUPT5H, FOS, MED1, GMEB1, DIDO1, PML, CEBPD, ZMYM3, SMAD1, VEZF1, TAF7, NCOA1, L3MBTL2, C11orf30, USF1, PHF20, REST, ZBTB7A, RBM25, ATF7, ZHX1, HNRNPLL, AFF1, BCOR, MBD2, MLLT1, NFATC3, KLF13, CBX3, MTA3, RBBP5, CREM, MEIS1, E2F8, CHD2, GTF2B, ZBED1, HOXB13, ZKSCAN1, YY1, RELA, JUNB, NEUROD1, ZFP36, SKIL, HIF1A, GATA3, TAL1, MAX, GATA1, MTA1, ZNF143, CBX2, CEBPG, NCOA3, GFI1B, NR2F2, ZNF544, ZNF512, NR2F1, KDM5B, PKNOX1, MYOD1, PHOX2B, BHLHE40, AR, TAF1, ZBTB40, EGLN2, EGR1, MYNN, RNF2, NCOR1, BRD4, JUND, SCRT1, ILF3, CUX1, NOTCH3, MAZ, ZNF24, ZNF316
- Target gene symbol (double-evidenced CRMs): VPS26C,KCNJ6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 38
- Number of somatic mutations (non-coding): 80
- Related genes and loops
- Related gene:
ENSG00000157538,
ENSG00000157542,
- Related loop:
chr21:36975000-37000000~~chr21:38125000-38150000,
chr21:37266529-37268622~~chr21:38120549-38122138,
chr21:37674157-37676230~~chr21:38125761-38128067,
chr21:37674162-37676306~~chr21:38125779-38127911,
chr21:37674191-37676998~~chr21:38125778-38127949,
chr21:37674274-37676281~~chr21:38125767-38127866,
chr21:37674327-37676274~~chr21:38125740-38127873,
chr21:37674344-37676262~~chr21:38125763-38127934,
chr21:37674476-37676308~~chr21:38125790-38127976,
chr21:37699607-37702263~~chr21:38125790-38127981,
chr21:37699731-37701840~~chr21:38125767-38127866,
chr21:37699733-37701770~~chr21:38125761-38128067,
chr21:37699764-37701688~~chr21:38125740-38127873,
chr21:37699767-37701789~~chr21:38125763-38127934,
chr21:37699782-37701775~~chr21:38125778-38127949,
chr21:37699800-37701800~~chr21:38125754-38127987,
chr21:37699813-37701825~~chr21:38125771-38127931,
chr21:37699831-37701768~~chr21:38125934-38127923,
chr21:37699842-37701862~~chr21:38125749-38127915,
chr21:37699849-37701736~~chr21:38125958-38127687,
chr21:37699862-37702222~~chr21:38125791-38127926,
chr21:37699932-37701752~~chr21:38126125-38127630,
chr21:37699988-37701699~~chr21:38126068-38127606,
chr21:37699994-37701579~~chr21:38126227-38127525,
chr21:37700000-37725000~~chr21:38100000-38125000,
chr21:37700000-37725000~~chr21:38125000-38150000,
chr21:37700007-37701742~~chr21:38126169-38127633,
chr21:37700028-37701831~~chr21:38125971-38127690,
chr21:37700066-37701913~~chr21:38126191-38127689,
chr21:37700073-37701763~~chr21:38126208-38127589,
chr21:37700099-37701668~~chr21:38126009-38127720,
chr21:37700112-37701685~~chr21:38125778-38127688,
chr21:37700162-37701530~~chr21:38126218-38127536,
chr21:37710487-37712977~~chr21:38125804-38127970,
chr21:37710499-37712987~~chr21:38125763-38127934,
chr21:37710638-37713716~~chr21:38125790-38127981,
chr21:37710736-37713758~~chr21:38125761-38128067,
chr21:37711372-37713046~~chr21:38125725-38127860,
chr21:37711392-37713025~~chr21:38125767-38127866,
chr21:37711392-37713166~~chr21:38125754-38127987,
chr21:37711394-37712982~~chr21:38125749-38127915,
chr21:37711395-37713012~~chr21:38125801-38127928,
chr21:37711396-37712996~~chr21:38125971-38127690,
chr21:37711397-37713457~~chr21:38125740-38127873,
chr21:37711406-37712950~~chr21:38125771-38127931,
chr21:37711408-37712950~~chr21:38125778-38127949,
chr21:37711418-37712993~~chr21:38125791-38127926,
chr21:37711434-37712961~~chr21:38126151-38127594,
chr21:37711434-37712993~~chr21:38125779-38127911,
chr21:37711438-37713000~~chr21:38125779-38127948,
chr21:37711441-37713006~~chr21:38125941-38127948,
chr21:37711442-37712977~~chr21:38126150-38127604,
chr21:37711445-37712965~~chr21:38125778-38127688,
chr21:37711446-37713025~~chr21:38125798-38127942,
chr21:37711455-37712980~~chr21:38125790-38127976,
chr21:37711462-37712982~~chr21:38126125-38127630,
chr21:37711467-37712985~~chr21:38125934-38127923,
chr21:37711574-37712971~~chr21:38126041-38127628,
chr21:37711651-37712969~~chr21:38126216-38127622,
chr21:37717141-37718351~~chr21:38125790-38127976,
chr21:37725000-37750000~~chr21:38125000-38150000,
chr21:37750000-37775000~~chr21:38100000-38125000,
chr21:37750000-37775000~~chr21:38125000-38150000,
chr21:37757478-37760684~~chr21:38125761-38128067,
chr21:37758041-37760564~~chr21:38125790-38127981,
chr21:37758054-37760218~~chr21:38125818-38127945,
chr21:37758083-37760394~~chr21:38120483-38122671,
chr21:37758083-37760394~~chr21:38125791-38127988,
chr21:37758088-37760278~~chr21:38125754-38127987,
chr21:37758111-37760132~~chr21:38125778-38127688,
chr21:37758115-37760170~~chr21:38120552-38122290,
chr21:37758115-37760170~~chr21:38125779-38127948,
chr21:37758129-37760281~~chr21:38125791-38127926,
chr21:37758130-37760186~~chr21:38126066-38127958,
chr21:37758140-37760150~~chr21:38125798-38127942,
chr21:37758144-37760203~~chr21:38125941-38127948,
chr21:37758163-37760055~~chr21:38125763-38127934,
chr21:37758198-37760138~~chr21:38125801-38127928,
chr21:37758212-37760210~~chr21:38125779-38127911,
chr21:37758230-37760229~~chr21:38125749-38127915,
chr21:37758324-37760023~~chr21:38125804-38127970,
chr21:37758368-37760158~~chr21:38125770-38127709,
chr21:37758370-37760095~~chr21:38125971-38127690,
chr21:37758391-37760172~~chr21:38126009-38127637,
chr21:37758410-37759974~~chr21:38125958-38127687,
chr21:37758419-37759941~~chr21:38125927-38127658,
chr21:37758428-37759911~~chr21:38125778-38127949,
chr21:37758446-37759976~~chr21:38125725-38127860,
chr21:37758468-37759930~~chr21:38126131-38127619,
chr21:37758479-37759910~~chr21:38126125-38127630,
chr21:37758513-37759885~~chr21:38126191-38127689,
chr21:37758520-37759866~~chr21:38126208-38127589,
chr21:37758563-37759871~~chr21:38126251-38127506,
chr21:37800000-37825000~~chr21:38125000-38150000,
chr21:37900000-37925000~~chr21:38125000-38150000,
chr21:37915283-37917809~~chr21:38125779-38127911,
chr21:37915315-37917747~~chr21:38125798-38127942,
chr21:37915343-37917688~~chr21:38126066-38127958,
chr21:37915529-37918394~~chr21:38125749-38127915,
chr21:37915593-37917649~~chr21:38125927-38127658,
chr21:37915609-37917622~~chr21:38125799-38127662,
chr21:37950000-37975000~~chr21:38125000-38150000,
chr21:38000000-38025000~~chr21:38100000-38125000,
chr21:38038817-38040294~~chr21:38125790-38127976,
chr21:38038824-38040349~~chr21:38125769-38128010,
chr21:38125000-38150000~~chr21:38250000-38275000,
chr21:38125000-38150000~~chr21:38275000-38300000,