- Basic information
- CohesinDB ID: CDBP00419091
- Locus: chr21-38135930-38141562
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Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR501LQA, ENCSR760NPX, ENCSR150EFU, ENCSR000ECS, GSE25021, ENCSR330ELC, GSE108869, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR806UKK, ENCSR703TNG, ENCSR199XBQ, ENCSR895JMI, ENCSR193NSH, ENCSR768DOX, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR676MJK, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, GSE68388, GSE126990, ENCSR748MVX
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Cell type: MCF-7, RPE, Fibroblast, Hela-Kyoto, A-549, HeLa-S3, Liver, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 24% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
69% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 44%,
"14_ReprPCWk": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, FOXA2, XBP1, ERF, FOXA1, ERG3, ERG2, ZNF28, HOXB13, KDM1A, ERG, RUNX2, RAD21, NRF1, PBX4, HIF1A, ARNT, NKX2-1, GATA3, GABPA, STAT3, MAX, UBN1, NKX3-1, FOS, RCOR1, TLE3, CEBPB, NCOA3, CREB1, TCF7L2, PIAS1, KDM5B, ETV1, JUN, TCF12, SP1, EP300, BAF155, EHF, SPI1, AR, GATA2, RBM25, ZHX1, ASH2L, BRD4, JUND, FOXP1, SMC3, FOSL2
- Target gene symbol (double-evidenced CRMs): KCNJ6,HLCS,KCNJ15
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159267,
ENSG00000157542,
ENSG00000157551,
- Related loop:
chr21:36975000-37000000~~chr21:38125000-38150000,
chr21:37700000-37725000~~chr21:38125000-38150000,
chr21:37710058-37714050~~chr21:38139516-38141430,
chr21:37725000-37750000~~chr21:38125000-38150000,
chr21:37750000-37775000~~chr21:38125000-38150000,
chr21:37800000-37825000~~chr21:38125000-38150000,
chr21:37900000-37925000~~chr21:38125000-38150000,
chr21:37917683-37919463~~chr21:38139516-38141430,
chr21:37950000-37975000~~chr21:38125000-38150000,
chr21:38125000-38150000~~chr21:38250000-38275000,
chr21:38125000-38150000~~chr21:38275000-38300000,