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Basic information

CohesinDB ID: CDBP00419095

Locus: chr21-38157453-38161826

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 73% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.189

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 69% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 41%, "14_ReprPCWk": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOXA1, ATF3, CTCFL, ZNF444, ZNF189, PAX5, JMJD1C, TEAD1, BCLAF1, ZNF121, TRIM28, ESR1, USF2, FUS, CTCF, JUN, BAF155, KLF1, MNT, LMO1, IRF4, ZNF528, SMC1, TEAD4, TFAP2C, EED, POU2F2, CHD8, ZNF263, POU5F1, CDK7, ZBTB48, SRF, ETS1, MYC, RAD21, GRHL3, GABPA, STAT3, ZNF614, XRCC5, UBN1, IKZF1, RCOR1, NFE2, MIER3, NR3C1, CEBPB, CREB1, EZH2, GRHL2, GABPB1, ZHX2, SPI1, GATA2, MRTFB, NFYB, RUNX1, SMC1A, CBX1, CEBPA, NKX2-2, POU4F2, SMAD3, ZNF654, NFXL1, TRIM22, SMARCC1, CREBBP, ZNF35, NFYC, ZBTB2, ZNF384, RUNX2, CDK6, ZNF184, PBX4, HMGB2, ATF2, NFYA, FOS, MED1, TEAD3, PIAS1, SMAD1, KLF16, BCL11A, REST, SMC3, STAG2, STAG1, FOXA2, MTA3, GTF2B, WT1, CDK9, HOXB13, ZNF580, YY1, RELA, JUNB, HIF1A, SKIL, GATA3, MAX, NRIP1, ZNF143, GATA1, KLF4, NCOA3, KDM5B, TP53, ELF3, AR, EGLN2, RB1, BRD4, JUND, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): ERG,KCNJ6,DYRK1A,TTC3,PSMG1,KCNJ15,ETS2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 32

Related genes and loops

Related gene: ENSG00000182670, ENSG00000157540, ENSG00000157542, ENSG00000157551, ENSG00000157554, ENSG00000157557, ENSG00000183527,

eachgene

Deatailed information for cohesin site CDBP00419095