- Basic information
- CohesinDB ID: CDBP00419115
- Locus: chr21-38227309-38230831
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR150EFU, GSE25021, GSE108869, ENCSR330ELC, GSE115602, GSE93080, ENCSR000DZP, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE135093, GSE120943, GSE206145-NatGen2015, ENCSR703TNG, GSE98367, ENCSR768DOX, GSE206145, GSE85526, ENCSR000ECE, ENCSR981FDC, ENCSR620NWG, ENCSR767DFK, GSE97394, GSE105004, GSE131956, GSE111913, ENCSR335RKQ, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR000ECS
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Cell type: HuCC-T1, H9-hESC, RPE, HMEC, Fibroblast, HEKn, HeLa-S3, IMR-90, K-562, H1-hESC, Monocytes, MB157, GM12878, GBM39, RT-112, Macrophage, HUES64, GM19099, MCF-7, Hela-Kyoto, HCT-116, A-549, HeLa, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 14% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.722
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
69% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"9_Het": 49%,
"15_Quies": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, ZNF391, CBX5, SOX2, XBP1, FOXA1, ZNF529, ZNF112, CHD7, ZBTB44, ZNF444, KLF14, ZNF189, SMARCE1, PAX5, MITF, JMJD1C, ZNF629, KLF5, ZNF586, TRIM28, ELF1, KLF6, ZNF26, BCLAF1, ZNF217, ESR1, HNF1B, OCA2, TP73, CTCF, TCF12, JUN, EP300, BAF155, ZNF157, GATA6, ZNF33A, DPF2, E2F6, TRIM24, ZNF211, E2F4, E2F1, ZNF528, ZNF350, ZNF280A, TEAD4, ZNF555, ZNF677, ZNF175, EHMT2, TFAP2C, GLIS1, NANOG, CHD8, POU2F2, ZSCAN5D, ZNF239, POU5F1, MYCN, ID3, RUNX1T1, CTBP1, MTA2, ZSCAN21, TOP2A, ZSCAN5A, STAT1, ARID3A, TBP, ERG, HOXC5, ZNF626, MYC, TSHZ1, RAD21, NKX2-1, GABPA, STAT3, XRCC5, IKZF1, RCOR1, NFE2, ZNF639, ZNF750, CEBPB, ZNF416, ZNF669, KLF8, GRHL2, TRPS1, ZHX2, SPI1, IRF1, ZNF257, KLF17, HDAC2, GATA2, SMARCA5, RELB, NCOA2, ZNF554, RUNX1, CBX1, SMC1A, CEBPA, SIN3A, ZFX, SMAD3, ZFP37, ZNF513, ZNF549, SMARCC1, CEBPZ, CREBBP, ZXDC, NOTCH1, ZNF169, RUNX2, ZSCAN30, GATA4, ZNF184, PBX4, ATF2, ZNF518A, ZEB2, MED1, ZNF558, ZNF680, PIAS1, ZMYM3, KLF9, SETDB1, ZNF37A, USF1, BCL11A, SP1, TFAP2A, MAFK, RBM25, ATF7, ZHX1, ASH2L, CTBP2, BCOR, FOXP1, SMC3, SKI, CBX3, MTA3, EBF1, RBBP5, FOXA2, ZNF600, ZNF30, ZNF662, CDK9, HOXB13, MPHOSPH8, KDM1A, YY1, RELA, ZNF148, ZNF155, ZNF510, ZNF610, TCF4, SKIL, HIF1A, ZFP36, GATA3, ZNF311, BATF, MAF1, MAX, NRIP1, ZNF143, SPIB, KLF4, SP7, NCOA3, GFI1B, ZNF544, TCF7L2, KDM5B, TP53, ZNF547, ELF3, BRD2, AR, TAF1, RBAK, ZNF324, EGLN2, ZNF280D, RB1, BRD4, ZNF248, MAZ, ZSCAN23, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): VPS26C
- Function elements
- Human SNPs: Educational_attainment_(MTAG)
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000157538,
- Related loop:
chr21:17775000-17800000~~chr21:38225000-38250000,
chr21:25200000-25225000~~chr21:38225000-38250000,
chr21:25450000-25475000~~chr21:38225000-38250000,
chr21:36500000-36525000~~chr21:38225000-38250000,
chr21:37250000-37275000~~chr21:38225000-38250000,
chr21:37325000-37350000~~chr21:38225000-38250000,
chr21:38200000-38225000~~chr21:38325000-38350000,
chr21:38200000-38225000~~chr21:38350000-38375000,
chr21:38200000-38225000~~chr21:39125000-39150000,
chr21:38225000-38250000~~chr21:38325000-38350000,
chr21:38225000-38250000~~chr21:38350000-38375000,
chr21:38225000-38250000~~chr21:42225000-42250000,
chr21:38233977-38237313~~chr21:38351817-38353514,
chr21:38234388-38237054~~chr21:38351763-38353495,