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Basic information

CohesinDB ID: CDBP00419118

Locus: chr21-38234603-38235613

Data sourse: ENCSR000BTQ, ENCSR000BTU, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE111913, GSE76893, GSE101921, GSE85526, GSE68388, ENCSR703TNG, GSE25021, GSE115602

Cell type: MCF-7, HMEC, HCT-116, HEKn, Ishikawa, RT-112, HSPC, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 8% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 69% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 78%, "7_Enh": 7%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SOX2, FOXA1, MEN1, BMI1, NFIC, WDHD1, SMARCE1, TP63, JMJD1C, KLF5, TEAD1, ELF1, KLF6, SNAI2, ZNF217, ESR1, HNF1B, JUN, TCF12, BAF155, EP300, GATA6, DPF2, PRKDC, NR5A2, SMC1, TEAD4, TFAP2C, NANOG, POU5F1, CTBP1, SRF, ERG, MYC, RAD21, NKX2-1, GABPA, STAT3, NKX3-1, RCOR1, ZNF750, CEBPB, ESRRA, NR3C1, CREB1, GRHL2, TRPS1, ZHX2, IRF1, HDAC2, GATA2, GATAD2B, HCFC1, NCOA2, RUNX1, CBX1, SMC1A, SIN3A, SMAD3, ZNF549, ZXDC, CREBBP, GATA4, PBX4, NFIB, ARNT, FOXM1, FOS, CHD1, MED1, ZEB1, PML, PIAS1, NR1H2, NIPBL, SP1, ATF7, ASH2L, CTBP2, MBD2, FOXP1, SMC3, STAG1, STAG2, FOXA2, HOXB13, KDM1A, YY1, RELA, TARDBP, JUNB, NEUROD1, TCF4, HIF1A, GATA3, MAX, NRIP1, ZNF143, KLF4, NCOA3, NR2F2, TCF7L2, KDM5B, TP53, PKNOX1, NFKB1, ELF3, AR, YAP1, EGLN2, EGR1, RB1, NCOR1, JUND, BRD4, CUX1, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): VPS26C

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 14

Related genes and loops

Related gene: ENSG00000157538,

eachgene

Deatailed information for cohesin site CDBP00419118