- Basic information
- CohesinDB ID: CDBP00419128
- Locus: chr21-38255085-38256173
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Data sourse: GSE138405, GSE67783, GSE68388, GSE98367
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Cell type: Macrophage, Hela-Kyoto, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,SA2,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
76% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 49%,
"14_ReprPCWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, XBP1, FOXA1, PBX2, NFIC, ZNF189, TP63, JMJD1C, TRIM28, NFE2L2, ESR1, TP73, JUN, TCF12, CTCF, EP300, GATA6, TFAP2C, GLIS1, CHD8, ZSCAN5D, ZNF263, RUNX1T1, KDM4C, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, MYC, EZH1, STAT3, RCOR1, NFE2, ZNF750, EZH2, KLF8, GRHL2, SPI1, GATA2, FLI1, HEXIM1-CDK9, RUNX1, MAFG, CBX1, SMC1A, SIN3A, ZFX, SMAD3, ZNF549, PRDM10, GATA4, ARNT, NFIB, PBX3, FOS, ZXDB, C11orf30, SETDB1, BCL11A, TCF3, SMC3, STAG1, WT1, RELA, ZFP36, HIF1A, GATA3, TAL1, MAX, NRIP1, GATA1, ZNF143, KLF4, SP7, NR2F2, ZSCAN22, ELF3, BRD2, BHLHE40, AR, PAX3-FOXO1, ZNF324, HSF1, BRD4, JUND, ZNF316
- Target gene symbol (double-evidenced CRMs): KCNJ6,KCNJ15,VPS26C
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000157538,
ENSG00000157542,
ENSG00000157551,
- Related loop:
chr21:31275000-31300000~~chr21:38250000-38275000,
chr21:36075000-36100000~~chr21:38250000-38275000,
chr21:36500000-36525000~~chr21:38250000-38275000,
chr21:37250000-37275000~~chr21:38250000-38275000,
chr21:38125000-38150000~~chr21:38250000-38275000,
chr21:38150000-38175000~~chr21:38250000-38275000,
chr21:38250000-38275000~~chr21:38750000-38775000,