- Basic information
- CohesinDB ID: CDBP00419129
- Locus: chr21-38256759-38258229
-
Data sourse: GSE98367, GSE206145, GSE85526, GSE206145-NatGen2015, GSE120943, GSE68388, GSE126755
-
Cell type: RPE, Fibroblast, Monocytes, HEKn, HuCC-T1, Neutrophil, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: NIPBL,Rad21,SMC1,Mau2,SMC3
-
CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
76% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 44%,
"14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, NME2, HNF1A, FOXA1, SUZ12, HNRNPK, BMI1, PRDM1, TP63, JMJD1C, TEAD1, ELF1, TRIM28, RBM39, SNAI2, NFE2L2, LMO2, ESR1, MLL, HNF1B, CTCF, TCF12, EP300, E2F6, TEAD4, ZSCAN5D, STAT1, ERG, SMARCA4, RAD21, GRHL3, GABPA, STAT3, RCOR1, HNRNPH1, VDR, ZNF750, CEBPB, NR3C1, KMT2A, CREB1, EZH2, ZHX2, SPI1, EHF, IRF1, GATA2, FLI1, RUNX1, CTNNB1, SMC1A, CEBPA, EZH2phosphoT487, SIN3A, PCBP2, CBX8, CREBBP, ZNF384, RUNX2, ARNT, PRDM9, FOS, CDK8, MED1, ZEB1, MYB, MAFK, NIPBL, BCL11A, SP1, NR4A1, NFATC3, SKI, FOXA2, MEF2C, HOXB13, RELA, GATA3, MAX, NRIP1, ZNF143, GATA1, TP53, ELF3, BHLHE40, AR, RXR, RNF2, BRD4, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): KCNJ6,KCNJ15,VPS26C
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 46
- Number of somatic mutations (non-coding): 2
- Related genes and loops
- Related gene:
ENSG00000157538,
ENSG00000157542,
ENSG00000157551,
- Related loop:
chr21:31275000-31300000~~chr21:38250000-38275000,
chr21:36075000-36100000~~chr21:38250000-38275000,
chr21:36500000-36525000~~chr21:38250000-38275000,
chr21:37250000-37275000~~chr21:38250000-38275000,
chr21:38125000-38150000~~chr21:38250000-38275000,
chr21:38150000-38175000~~chr21:38250000-38275000,
chr21:38250000-38275000~~chr21:38750000-38775000,