- Basic information
- CohesinDB ID: CDBP00419131
- Locus: chr21-38260291-38265425
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Data sourse: ENCSR853VWZ, GSE206145-GSE177045, GSE67783, GSE72082, ENCSR193NSH, ENCSR501LQA, GSE138405, GSE165895, GSE115602, ENCSR404BPV, ENCSR150EFU, ENCSR335RKQ, GSE206145-NatGen2015, GSE206145, GSE83726, ENCSR199XBQ, GSE126990, ENCSR217ELF
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Cell type: MCF-7, RPE, Fibroblast, Hela-Kyoto, RH4, Neurons-H1, A-549, HSPC, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 11% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
76% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 30%,
"5_TxWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, NME2, XBP1, FOXA1, NFIC, CBFB, DPF1, MITF, HDAC3, JMJD1C, TEAD1, ELF1, ZNF217, ESR1, USF2, CTCF, TCF12, JUN, BAF155, EP300, RAD51, NR5A2, TEAD4, TFAP2C, NANOG, POU2F2, CHD8, ZSCAN5D, BRD3, TOP2A, CTBP1, ZNF300, ERG, OGG1, MYC, RXRA, STAT3, NKX3-1, TERF2, NR3C1, CEBPB, ESRRA, CREB1, EZH2, GRHL2, ZHX2, SPI1, HDAC2, GATA2, SIX2, ATF1, RUNX1, CEBPA, SIN3A, ZFX, SMAD3, CREBBP, ZNF133, RUNX2, GATA4, NRF1, NFIB, ARNT, PBX4, ATF2, PRDM9, PBX3, FOS, MED1, PIAS1, NCOA1, USF1, SP1, MAFK, HNF4A, REST, ZNF479, ATF7, CTBP2, FOXP1, SMC3, NCOR2, STAG1, ZNF283, CBFA2T2, FOXA2, FOXF1, HOXB13, BCL3, RELA, HIF1A, GATA3, BATF, MAX, PLAG1, TLE3, NCOA3, NR2F2, TP53, ZNF334, MYOD1, BHLHE40, AR, RNF2, BRD4, CLOCK, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): KCNJ6,VPS26C,KCNJ15
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 200
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000157538,
ENSG00000157542,
ENSG00000157551,
- Related loop:
chr21:31275000-31300000~~chr21:38250000-38275000,
chr21:36075000-36100000~~chr21:38250000-38275000,
chr21:36500000-36525000~~chr21:38250000-38275000,
chr21:37250000-37275000~~chr21:38250000-38275000,
chr21:38125000-38150000~~chr21:38250000-38275000,
chr21:38150000-38175000~~chr21:38250000-38275000,
chr21:38218492-38220499~~chr21:38268300-38270566,
chr21:38218530-38220189~~chr21:38267684-38270477,
chr21:38218546-38219987~~chr21:38269172-38270349,
chr21:38250000-38275000~~chr21:38750000-38775000,
chr21:38269135-38270391~~chr21:38333337-38334718,