- Basic information
- CohesinDB ID: CDBP00419132
- Locus: chr21-38265648-38270119
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Data sourse: GSE93080, ENCSR000EAC, ENCSR000DZP, ENCSR230ZWH, GSE98367, GSE138405, GSE165895, ENCSR000BLY, GSE206145, GSE85526, GSE206145-NatGen2015, ENCSR000BMY, GSE120943, GSE68388, GSE103477, GSE111537, GSE50893, GSE126755, ENCSR917QNE
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Cell type: OCI-AML-3, Liver, HuCC-T1, B-cell, RPE, GM2630, Fibroblast, HEKn, GM12890, GM2255, GM18486, HFFc6, GM18526, SNYDER, Monocytes, GM12878, GM12891, GM2588, SK-N-SH, GM19239, GM19193, THP-1, GM19099, Macrophage, GM12892, Hela-Kyoto, GM19238, Neutrophil
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 14% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.689
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
76% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 33%,
"15_Quies": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RELA, AR, OGG1, REST, ZNF496, BRD3, ZNF263, RUNX2, MYC, ZFX, EZH2, XBP1, ESR1, BRD4, WT1, GRHL3, OCA2, SUZ12, ZNF143
- Target gene symbol (double-evidenced CRMs): VPS26C,KCNJ15,KCNJ6
- Function elements
- Human SNPs: Waist-to-hip_ratio_adjusted_for_BMI
- Number of somatic mutations (coding): 132
- Number of somatic mutations (non-coding): 16
- Related genes and loops
- Related gene:
ENSG00000157538,
ENSG00000157542,
ENSG00000157551,
- Related loop:
chr21:31275000-31300000~~chr21:38250000-38275000,
chr21:34525000-34550000~~chr21:38275000-38300000,
chr21:36075000-36100000~~chr21:38250000-38275000,
chr21:36500000-36525000~~chr21:38250000-38275000,
chr21:37250000-37275000~~chr21:38250000-38275000,
chr21:37350000-37375000~~chr21:38275000-38300000,
chr21:38125000-38150000~~chr21:38250000-38275000,
chr21:38125000-38150000~~chr21:38275000-38300000,
chr21:38150000-38175000~~chr21:38250000-38275000,
chr21:38218492-38220499~~chr21:38268300-38270566,
chr21:38218530-38220189~~chr21:38267684-38270477,
chr21:38218546-38219987~~chr21:38269172-38270349,
chr21:38250000-38275000~~chr21:38750000-38775000,
chr21:38269135-38270391~~chr21:38333337-38334718,