- Basic information
- CohesinDB ID: CDBP00419135
- Locus: chr21-38273791-38279650
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Data sourse: ENCSR501LQA, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, ENCSR000ECS, GSE103477, GSE111537, ENCSR330ELC, GSE108869, ENCSR000BUC, GSE165895, ENCSR000EFJ, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE135093, GSE120943, GSE206145-NatGen2015, GSE112028, ENCSR199XBQ, ENCSR895JMI, GSE118494, GSE98367, ENCSR193NSH, ENCSR768DOX, GSE206145, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, GSE105004, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR000HPG, ENCSR676MJK, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, GSE68388, GSE126990, GSE126755, ENCSR748MVX, GSE73207
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Cell type: MDM, HuCC-T1, RPE, HMEC, Fibroblast, HEKn, HeLa-S3, Neutrophil, IMR-90, HFFc6, Monocytes, TF-1, SK-N-SH, HeLa-Tet-On, Macrophage, Hela-Kyoto, A-549, HeLa, OCI-AML-3
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 29% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.789
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
76% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 38%,
"5_TxWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, SKI, SMC1A, CEBPA, E2F7, SOX2, ZFX, STAT1, FOXA1, MEF2C, TFAP4, ERG, RELA, KDM1A, RUNX2, MYC, EZH1, GATA4, RAD21, GRHL3, ARNT, CBFB, CDK8, NFE2, NR3C1, JMJD1C, SP7, CEBPB, TRIM28, KMT2A, NEUROG2, TP53, ESR1, TP73, USF2, CTCF, ELF3, SPI1, BHLHE40, IRF1, GATA6, INTS13, BRD4, ZNF316
- Target gene symbol (double-evidenced CRMs): KCNJ6,VPS26C,KCNJ15,DYRK1A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 210
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000157538,
ENSG00000157540,
ENSG00000157542,
ENSG00000157551,
- Related loop:
chr21:31275000-31300000~~chr21:38250000-38275000,
chr21:34525000-34550000~~chr21:38275000-38300000,
chr21:36075000-36100000~~chr21:38250000-38275000,
chr21:36500000-36525000~~chr21:38250000-38275000,
chr21:37250000-37275000~~chr21:38250000-38275000,
chr21:37350000-37375000~~chr21:38275000-38300000,
chr21:38125000-38150000~~chr21:38250000-38275000,
chr21:38125000-38150000~~chr21:38275000-38300000,
chr21:38150000-38175000~~chr21:38250000-38275000,
chr21:38218492-38220499~~chr21:38268300-38270566,
chr21:38218530-38220189~~chr21:38267684-38270477,
chr21:38218546-38219987~~chr21:38269172-38270349,
chr21:38250000-38275000~~chr21:38750000-38775000,
chr21:38269135-38270391~~chr21:38333337-38334718,