- Basic information
- CohesinDB ID: CDBP00419138
- Locus: chr21-38282614-38284469
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Data sourse: ENCSR501LQA, ENCSR760NPX, ENCSR150EFU, GSE111537, ENCSR330ELC, GSE108869, GSE206145-NatGen2015, ENCSR806UKK, GSE120943, ENCSR199XBQ, ENCSR895JMI, GSE98367, ENCSR193NSH, ENCSR768DOX, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR676MJK, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, GSE126755, ENCSR748MVX
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Cell type: RPE, Fibroblast, Monocytes, A-549, OCI-AML-3, HeLa-S3, Neutrophil, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 14% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
76% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 40%,
"5_TxWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, SKI, FOXO1, PGR, SMC1A, PPARG, CEBPA, BRD3, XBP1, ZFP3, MAFF, STAT1, FOXA1, ZNF205, RELA, CREBBP, CHD4, JUNB, RUNX2, MYC, RAD21, GRHL3, RXRA, GABPA, STAT3, ZNF143, CDK8, RCOR1, FOS, NFE2, MED1, NR3C1, CEBPB, JMJD1C, NCOA3, TRIM28, KMT2A, ETV1, SMAD1, ESR1, C11orf30, NFKB1, CTCF, JUN, MAFK, SPI1, EP300, BCL11A, SP1, AR, IRF1, HNF4A, RXR, BRD4, NR1H3, ZNF316
- Target gene symbol (double-evidenced CRMs): DYRK1A,KCNJ15,KCNJ6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 98
- Number of somatic mutations (non-coding): 0
- Related genes and loops