- Basic information
- CohesinDB ID: CDBP00419139
- Locus: chr21-38284801-38299034
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Data sourse: ENCSR000BLD, ENCSR230ZWH, ENCSR501LQA, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, ENCSR000ECS, GSE103477, GSE111537, ENCSR330ELC, GSE108869, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE67783, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE135093, GSE120943, GSE206145-NatGen2015, GSE112028, ENCSR199XBQ, GSE116344, ENCSR895JMI, GSE118494, GSE98367, ENCSR193NSH, ENCSR768DOX, GSE206145, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, GSE105004, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE68388, GSE126990, GSE126755, ENCSR748MVX
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Cell type: MDM, RH4, Liver, HuCC-T1, RPE, HMEC, Fibroblast, HEKn, HeLa-S3, Neutrophil, IMR-90, HFFc6, H1-hESC, Monocytes, SK-N-SH, RT-112, HeLa-Tet-On, THP-1, Macrophage, Hela-Kyoto, A-549, HeLa, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 32% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.733
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
76% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 36%,
"5_TxWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: POU2F2, CHD8, BRD3, SIN3A, ZFX, XBP1, FOXA1, HOXB13, RELA, RUNX2, CDK6, GRHL3, STAT3, FOS, ZNF143, JMJD1C, NCOA3, SCRT2, SNAI2, LMO2, TP53, CTCF, MAFK, SPI1, AR, NOTCH3, BRD4, SCRT1, TFAP2C
- Target gene symbol (double-evidenced CRMs): KCNJ6,DYRK1A,KCNJ15
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 553
- Number of somatic mutations (non-coding): 30
- Related genes and loops